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Drug Transporters
Volume 2: Recent Advances and Emerging Technologies
Web PDF
Sofort lieferbar | Lieferzeit: Sofort lieferbar I
ISBN-13:
9781782628705
Veröffentl:
2016
Einband:
Web PDF
Seiten:
239
Autor:
Glynis Nicholls
Serie:
ISSN
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
2 - DRM Adobe
Sprache:
Englisch
Beschreibung:
Understanding and quantifying the effects of membrane transporters within the human body is essential for modulating drug safety and drug efficacy. The first volume comprehensively reviewed current knowledge and techniques in the transporter sciences and their relations to drug metabolism and pharmacokinetics. In this second volume on Drug Transporters, emphasis is placed on emerging sciences and technologies, highlighting potential areas for future advances within the drug transporter field.
Overview of drug transporter families and their role in drug development; Liver transporters and their involvement in the hepatocellular uptake and export systems of organic anions; Intestinal transporters; Kidney transporters; CNS transporters; Lung transporters; The use of in vitro and in silico systems for investigating transporter interactions; The use of transgenic and knockout in vivo systems for investigating transporter interactions; Modelling and simulation of transporter interactions; Clinical Drug-Drug Interactions: An industrial Pharmaceutical Perspective; Regulatory requirements, Labelling and Drug Transporters; Recent Advances and Emerging Technologies; Bioinformatics; Regulation of transporters; Transporter Pharmacogenomics; Transporter Imaging; Transporters and Proteomics
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