Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell-Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.

Includes supplementary material: sn.pub/extras

Part I. Polyamines in Signal Transduction of Cell ProliferationPolyamine Structure and Synthetic AnalogsPatrick M. WosterAcute Increases in Intracellular Putrescine Lead to the Increase in Steady-State Levels of c-fos, c-jun, RING3, and Id-1 mRNAsAllan A. Ancheta, Leo Hawel, III, and Craig V. ByusPolyamine-Dependent Early Cellular Signals and Cell ProliferationStina M. OredssonCellular Signals Mediating Growth Arrest After Polyamine DepletionJian-Ying WangRole of Polyamines in the Regulation of Chromatin AcetylationCheryl A. Hobbs and Susan K. GilmourRole of Polyamines in Regulation of Sequence-Specific DNA Binding ActivitySripriya Venkiteswaran, Thresia Thomas, and T. J. ThomasPolyamine Metabolism and the Hypertrophic HeartLisa M. Shantz and Emanuele GiordanoInfluence of Polyamines on Breast Cancer BiologyAndrea ManniPolyamines in Regulation of Prostatic Cell GrowthRaymond G. Schipper, Vincent Cuijpers, Johannes C. Romijn, and Albert A. J. VerhofstadPolyamines in Kidney BiologyJoseph SatrianoPolyamines in Pulmonary Vascular BiologyJack W. Olson and Mark N. GillespiePart II. Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer TherapyRecent Advances in the Understanding of Mammalian Polyamine Catabolism: The Regulation and Potential Role of Polyamine Catabolism in Drug Response and Disease ProcessesRobert A. Casero, Jr., Alison V. Fraser, Tracy Murray-Stewart, Amy Hacker, Naveen Babbar, Jennifer Fleischer, and Yanlin WangCellular Signaling and Polyamines in the Control of Apoptosis in Intestinal Epithelial CellsLeonard R. Johnson and Ramesh M. RayThe Role of Ornithine Decarboxylase in Myc-Induced TumorigenesisJonas A. Nilsson and John L. ClevelandProtective Effect of Polyamines on NSAID-Induced Injury and ApoptosisHeather M. Wallace and Alun HughesRole of Polyamines in the Control of the Immune Response in the BrainDenis Soulet and Serge RivestImplication of Polyamines in Apoptosis of Immunoresponse CellsRupesh Chaturvedi and Keith T. WilsonPolyamines and CancerAjit K. VermaPolyamine Pools and Cancer PreventionEugene W. Gerner and David E. StringerPart III. Polyamines in Cell Motility and Cell-Cell InteractionsPolyamines and Cytoskeletal Regulation During Intestinal Epithelial RestitutionRamesh M. Ray and Leonard R. JohnsonRegulation of Kv Channel Activity and Intercellular Junctions by Polyamines in Intestinal Epithelial CellsJaladanki N. Rao and Jian-Ying WangPolyamine Block of Kir Channels: Toward a Molecular PictureHarley T. Kurata and Colin G. NicholsPart IV. Polyamine Homeostasis and TransportRegulation of Ornithine Decarboxylase ExpressionLo PerssonEvidence for a Multistep Model for Eukaryotic Polyamine TransportRichard Poulin, Denis Soulet, Bruno Gagnon, Serge Rivest, and Marie AudetteBacterial and Eukaryotic Transport SystemsKazuei Igarashi and Keiko KashiwagiRegulation of S-Adenosylmethionine DecarboxylaseColin HanfreyGenetic Engineering of Polyamine Catabolism in Transgenic Mice and RatsJuhani Jänne, Leena Alhonen, Marko Pietilä, Tuomo A. Keinänen, Suvikki Suppola, Eija Pirinen, Mervi T. Hyvönen, Aki Järvinen, and Markku LaaksoIndex