Table 1 Cancer is the second most common cause of death in Americans (see cdc.gov). Colorectal cancer kills more Incidence and Mortality of the Five Most Common Gastrointestinal Malignancies Americans than any other malignancy except for lung cancer. The incidences and mortalities of the major gastrointestinal a a Site Incidence Mortality (GI) malignancies are shown in Table 1. Taken as a group, the five most common GI malignancies account for more cancers Colorectum 53.9 21.6 and more cancer deaths than for any other site. Pancreas 11.1 10.6 Stomach 9.1 4.9 Flexible endoscopy has given physicians unprecedented Liver/intrahepatic bile ducts 6.2 4.4 access to the GI tract. The ability to endoscopically visu- Esophagus 4.5 4.3 alize, biopsy, and apply therapy has had implications for the management of all the major GI malignancies. Accepted Data from SEER database 1992¿2002 (seer.cancer.gov). applications of endoscopy range from detection of mal- a Per 100,000.

Includes supplementary material: sn.pub/extras

Part I. EsophagusBarrett's Esophagus: Screening, Diagnosis, and ManagementGlenn M. EisenEndoscopic Screening for Squamous Cell Carcinoma of the EsophagusBrian C. JacobsonImage Enhancement EndoscopyStephan M. Wildi and Michael B. WallaceStaging of Esophageal CancerJason Vollweiler and Gregory Zuccaro, Jr.Endoscopic Therapy for Early Esophageal Cancer and Premalignant Lesions in Barrett's EsophagusGanapathy A. Prasad and Kenneth K. WangEndoscopic Therapy for Advanced Esophageal CancerSanjay Jagannath and Marcia I. CantoRadiological Imaging of the Upper Gastrointestinal TractMarc S. LevineEsophageal Cancer Therapy: Surgery, Radiation, and ChemotherapyJohn M. Holland and Christopher A. CanningPart II. Stomach and Small BowelPremalignant Lesions of the StomachOmid A. Shaye and Andrew IppolitiGastric PolypsGeorge A. Makar and Gregory G. GinsbergEndoscopic Ultrasound for Staging Gastric CancerGregory Olds and Amitabh ChakEndoscopic Treatment for Gastric CancerTakuji Gotoda and Roy M. SoetiknoDiagnosis and Management of Gastrointestinal LymphomaJohn G. Kuldau, Peter R. Holman, and Thomas J. SavidesGastrointestinal Stromal TumorsRaquel E. DavilaCarcinoid TumorsWillscott E. Naugler and Gordon C. HuntMedical and Surgical Therapy for Gastric CancerDiane HershockPart III. ColonColorectal Cancer ScreeningJason A. Dominitz and William M. GradyPolyposis and Familial Cancer SyndromesFernando S. Velayos, Madhulika G. Varma, and Jonathan P. TerdimanEndoscopic Colon Surveillance: Post-Polypectomy, Post-Colorectal Cancer Resection, and Inflammatory Bowel DiseaseDouglas B. Nelson and Mandeep S. SawhneyEndoscopic Ultrasound for Staging Rectal and Anal CancerDeepak V. GopalEndoscopic Therapy of Colorectal CarcinomaVaman Jakribettuu and Yang K. ChenRadiological Imaging of the Lower Gastrointestinal TractStephen E. RubesinCurrent Status of Colorectal Cancer TherapyJohn Strother, Kevin G. Billingsley, Arthur Y. Hung, and Charles D. BlankePart IV. Pancreas, Bile Ducts, and MediastinumCystic Neoplasms of the PancreasWilliam R. BruggeDiagnosis and Evaluation of Pancreatic Ductal AdenocarcinomaKenneth H. Yu and Nuzhat A. AhmadAdenocarcinoma of the Pancreas: Endoscopic PalliationGeorgios I. Papachristou, Kevin McGrath, and Adam SlivkaPancreatic Neuroendocrine TumorsErik-Jan Wamsteker and James M. ScheimanEndoscopic Diagnosis and Management of CholangiocarcinomaVanessa M. Shami and Irving WaxmanAmpullary NeoplasiaIan D. NortonMagnetic Resonance Imaging of Neoplasms of the Pancreatobiliary SystemEvan S. Siegelman and Wendy C. HsuMedical and Surgical Therapy of Pancreatic CancerWeijing Sun, Jon Morris, and Jeffrey DrebinEndoscopic Ultrasound for Thoracic DiseaseTimothy Woodward, Massimo Raimondo, and Michael B. WallaceIndex