A comprehensive survey by leading basic and clinical researchers of the signal transduction mechanisms responsible for lung inflammation, including vascular hyperpermeability, white cell accumulation, and vascular remodeling. The authors cut across disciplines to bring together a broad-based presentation of inflammatory challenge, both in the initial phases of the inflammatory response, as well as in the more prolonged phase of genomic involvement. The book illuminates not only the processes of lung inflammation, but also the potential for developing new therapeutic strategies to combat inflammatory lung disease.

Includes supplementary material: sn.pub/extras

Heme Oxygenase-1 and Carbon Monoxide in Vascular Regulation Stefan W. Ryter and Augustine M. K. Choi

Tumor Necrosis Factor-a/Receptor Signaling Through the Akt Kinase
Osman Nidai Ozes, Hakan Akca, Jason A. Gustin, Lindsey D. Mayo, Roxana Pincheira, Chandrashekhar K. Korgaonkar, and David B. Donner

Protein Modifications by Nitric Oxide and Reactive Nitrogen Species
Harry Ischiropoulos

Redox Signaling in Hypoxic Pulmonary Vasoconstriction
E. Kenneth Weir, Zhigang Hong, Anthony Varghese, Daniel P. Nelson, and Andrea Olschewski

cGMP-Dependent Protein Kinase in Regulation of the Perinatal Pulmonary Circulation
Usha Raj, Yuansheng Gao, Srinivas Dhanakoti, and Fred Sander

Glutamate Receptor Activation in the Pathogenesis of Acute Leg Injury
Sami I. Said

Carboxyl Methylation of Small GTPases and Endothelial Cell Function
Sharon Rounds, Elizabeth O. Harrington, and Qing Lu

Pressure-Induced Inflammatory Signaling in Lung Endothelial Cells
Wolfgang M. Kuebler

Regulation of Endothelial Barrier Function: Contributions of the Transcellular and Paracellular Pathways
Dolly Mehta, Richard D. Minshall, and Asrar B. Malik

Sphingolipid Signaling: Implications for Vascular Biology
Margaret M. Harnett

Regulations of Cytokine Signaling
Bao Q. Vuong, Lisa McKeag, Julie A. Losman, Jianze Li, Alex Banks, Scott Fay, Peter Chen, and Paul Rothman

Cell Signaling by Vasoactive Agents
Barry L. Fanburg, Regina M. Day, Amy R. Simon, Sheu-Ling Lee, and Yuichiro J. Suzuki

Reactive Oxygen Species and Cell Signaling in Lung Ischemia
Aron B. Fisher

Pulmonary Vascular Barrier Regulation by Thrombin and Edg Receptors
Jeffrey R. Jacobson and Joe G. N. Garcia

Second-Messenger Signaling in Lung Capillaries
Kaushik Parthasarathi

Plasma Membrane-to-Nucleus Calcium Signaling
Giles E. Hardingham

Signaling by Mitochondria
Navdeep S. Chandel

Pro-Inflammatory Signaling by Endothelial Focal Complexes in Lung
Sunita Bhattacharya

Hydrogen Peroxide As Intracellular Messenger: Production, Target, and Elimination
Sue Goo Rhee, Tong-Shin Chang, Yun Soo Bae, Seung-Rock Lee, and Sang Won Kang

Calcium-Inhibited Adenylyl Cyclase (AC6) Controls Endothelial Cell Barrier Function
Troy Stevens

Index