Despite dizzyingly fast-paced advances over the past two decades, even the definition of Polycystic Ovarian Syndrome (PCOS) remains in dispute. Insulin Resistance and Polycystic Ovarian Syndrome: Pathogenesis, Evaluation, and Treatment highlights the recent transition of PCOS from an infertility disorder with a diagnosis based on ovarian tissue histology to a more complex clinical entity, a metabolic disorder in which insulin resistance plays a central role. With an expert panel of authors, each chapter provides an up-to-date and balanced overview of PCOS, paying special attention to the central role of insulin resistance in the syndrome¿s pathogenesis and in the management of its reproductive and metabolic abnormalities.Comprehensive and thought-provoking, Insulin Resistance and Polycystic Ovarian Syndrome: Pathogenesis, Evaluation, and Treatment is an invaluable resource for endocrinologists, gynecologists, and internists eager to learn more about this controversial and challenging disease.

An up-to-date and balanced overview of PCOS, with specific attention to the role of insulin resistance in its pathogenesis

Evaluation for Insulin Resistance and Comorbidities Related to Insulin Resistance in Polycystic Ovary Syndrome.- Fat Distribution and Adipose Products in Polycystic Ovary Syndrome.- Treatment of Infertility in Polycystic Ovary Syndrome.- Imaging Studies in Polycystic Ovary Syndrome.- Genes Related to Metabolic Abnormalities or Insulin Resistance in Polycystic Ovary Syndrome.- Anti-Androgens.- Lipid Abnormalities in Polycystic Ovary Syndrome.- Serine Phosphorylation, Insulin Resistance, and the Regulation of Androgen Synthesis.- Chronic Treatment of Polycystic Ovary Syndrome.- Insulin-Sensitizing Drugs for the Treatment of Infertility in Polycystic Ovary Syndrome.- Diet and Lifestyle Factors in the Etiology and Management of Polycystic Ovary Syndrome.- Adrenarche.- Cardiovascular Disease and Inflammation.- Surgery and Laser Diathermy.- Late Pregnancy Complications in Polycystic Ovary Syndrome.- Glucose Intolerance.- Hormonal and Biochemical Evaluation of Polycystic Ovary Syndrome.- Endometrial Carcinoma in Polycystic Ovary Syndrome.- Statins, Oxidative Stress, and Polycystic Ovary Syndrome.- Glucose Intolerance in Polycystic Ovary Syndrome.- Polycystic Ovary Syndrome.- Anovulation in Polycystic Ovary Syndrome.- Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome.- "Secondary" Polycystic Ovary Syndrome.- Long-Term Sequelae of Polycystic Ovary Syndrome.- The Insulin Resistance of Polycystic Ovary Syndrome.- Therapeutic Aspects of Polycystic Ovary Syndrome in Adolescence.- Lifestyle Intervention in Polycystic Ovarian Syndrome.- Involvement of the Endocannabinoid System in Metabolism and Fertility.- Insulin Resistance.- Clinical Evaluation of Polycystic Ovary Syndrome.- Pharmaceutical Intervention in Metabolic and Cardiovascular risk Factors in Polycystic OvarySyndrome.- Insulin Resistance and Early Pregnancy Loss in Polycystic Ovary Syndrome.