The increasing prevalence of diabetes and obesity in western societies today makes these two diseases the leading epidemics of the 21st century. Closely linked with the development of serious complications, including cardiovascular disease and several malignancies, the morbidity and mortality associated with obesity and diabetes will continue to escalate as the population ages and becomes more sedentary. In Obesity and Diabetes, international experts from world-renowned medical schools comprehensively review for practicing clinicians and scientists alike the latest understanding of the epidemiology, causation, and consequences of diabetes and obesity. The authors discuss in detail their diagnosis, clinical manifestations, complications, and best practices for diagnosis and treatment. They also review the history and epidemiology of these conditions, explain their genetics and pathophysiology, and illuminate their known mechanisms and interactions. State-of-the-art survey-chapters critique current approaches (lifestyle and pharmacological) to the treatment of these conditions.Authoritative and up-to-date, Obesity and Diabetes offers a comprehensive review of the scientific and clinical aspects of obesity and diabetes, even while providing a powerful incentive to focus our public health efforts on prevention and our clinical efforts on treatment.

Includes supplementary material: sn.pub/extras

History and Epidemiology.- Obesity and Diabetes.- Epidemiology of Obesity and Diabetes.- Genetics and Pathophysiology.- Genetics of Obesity and Diabetes.- Nutrients and Peripherally Secreted Molecules in Regulation of Energy Homeostasis.- Central Integration of Peripheral Signals in Regulation of Energy Homeostasis.- Role of Energy Expenditure in Regulation of Energy Homeostasis.- Pathophysiology of Diabetes in Obesity.- Diagnosis, Clinical Manifestations, and Complications.- Diagnosing Obesity, Diabetes Mellitus, and Insulin Resistance Syndrome.- Metabolic Syndrome.- Obesity, Diabetes, and Hypertension.- Dyslipidemia Associated With Diabetes and Insulin Resistance Syndromes.- Obesity, Diabetes, and Endothelial Dysfunction.- Atherosclerosis and Peripheral Vascular Disease.- Obesity, Diabetes, and Risk of Cancer.- Polycystic Ovary Syndrome and Its Metabolic Complications.- Obesity and Type 2 Diabetes Mellitus in Childhood and Adolescence.- Diabetic Retinopathy.- Obesity and Renal Disease.- Diabetic Peripheral Neuropathy.- The Diabetic Foot.- Erectile Dysfunction.- Infections in Diabetes Mellitus.- The HAART-Induced Metabolic Syndrome.- Treatment.- Diet and Lifestyle in Prevention and Management of Type 2 Diabetes.- Diet, Exercise, and Behavioral Treatment of Obesity.- Medical Approaches to Treatment of the Obese Patient.- Treatment of the Obese Patients With Type 2 Diabetes.- Surgical Treatment of Obesity and Diabetes.- Future Developments in the Area of Pharmacotherapy.