are new to this edition. The authors provide not only the The second edition of Thyroid Cancer: A Comp- most current review of their respective areas, but also their hensive Guide to Clinical Management marks the pub- own recommendations and approach. The reader is fo- cation of a markedly updated and expanded volume that warned that in many cases these approaches, albeit rooted covers all aspects of the etiology, pathogenesis, diag- sis, initial treatment, and long-term management of all in available data, may be empiric rather than based varieties of thyroid cancer. Like the first edition, it will upon clear-cut results of well-controlled clinical t- als. Nevertheless, controversial issues are examined serve as a valuable reference source for pathologists, and evidence-based recommendations are presented endocrine surgeons, endocrinologists, nuclear medicine when available. physicians, and oncologists. However, the biggest There are updated chapters on our current state change is that the second edition is significantly enlarged and expanded to encompass important and extensive of knowledge of the molecular changes in thyroid treatments of more topics related to nuclear medicine. cancer, molecular markers, and how targeted the- pies are being developed. New therapeutic trials of Nuclear medicine physicians and procedures play a key redifferentiation agents to restore the sodium iodide role in the management of thyroid cancer patients and in symporter when lacking and more traditional che- retrospect, a comprehensive discussion of topics related therapies are discussed, with referral sources listed for to that field was somewhat lacking in the first edition.

In this newly updated and revised second edition, Leonard Wartofsky, MD, past president of the American Thyroid Association, and a panel of world-class clinicians critically review all aspects of thyroid cancer from pathogenesis to prognosis, including management and treatment. Organized for rapid access by busy physicians, the book covers both differentiated tumors (papillary carcinoma and follicular carcinoma) and undifferentiated cancers (anaplastic carcinoma, lymphoma, and medullary carcinoma), as well as miscellaneous and unusual cancers of the thyroid. For each tumor type the authors succinctly discuss the key aspects of their clinical presentation, cytology, diagnosis, nuclear isotope scanning evaluation, cellular and biochemical markers, imaging by MRI or CT, monitoring, surgery, pathology, post-operative care, and prognosis. Authoritative and evidenced-based, this second edition of Thyroid Cancer: A Comprehensive Guide to Clinical Management provides in one place everything that physicians treating thyroid cancer patients need to know.

Part I. General Considerations I: Thyroid Cancer
Anatomy and Physiology of the Thyroid Gland: Clinical Correlates to Thyroid Cancer
Nikolaos Stathatos

Epidemiology of Thyroid Cancer
James J. Figge

Molecular Pathogenesis of Thyroid Cancer
James J. Figge, Nikolai A. Kartel, Dima Yarmolinsky, and Gennady Ermak

Molecular Aspects of Thyroid Cancer in Children
Gary L. Francis

Oncogenes in Thyroid Cancer
Katherine B. Weber and Michael T. McDermott

Apoptosis in Thyroid Cancer
Su He Wang and James R. Baker, Jr.

Radiation-Induced Thyroid Cancer
James J. Figge, Timothy Jennings, Gregory Gerasimov, Nikolai A. Kartel, Dima Yarmolinsky, and Gennady Ermak

Classification of Thyroid Malignancies
Yolanda C. Oertel

Staging of Thyroid Cancer
Leonard Wartofsky

Thyroid Cancer in Children and Adolescents
Merrily Poth

Recombinant Human Thyrotropin
Matthew D. Ringel and Stephen J. Burgun

Part II. General Considerations II: Nuclear Medicine

History of the Role of Nuclear Medicine in the Thyroid Gland and its Diseases: A Personal Perspective
Henry N. Wagner, Jr.

Prophylaxis against Radiation Exposure from Radioiodine
Jacob Robbins and Arthur B. Schneider

Radioiodine Whole Body Imaging
Frank B. Atkins and Douglas Van Nostrand

Primer and Atlas for the Interpretation of Radioiodine Whole-Body Scintigraphy
Douglas Van Nostrand, Reetha Bakthula, and Frank B. Atkins

False-Positive Radioiodine Scans in Thyroid Cancer
Brahm Shapiro, Vittoria Rufini, Ayman Jarwan, Onelio Geatti, Kimberlee J. Kearfott, Lorraine M. Fig, Ian D. Kirkwood, John E. Freitas, and Milton D. Gross

Part III. The Thyroid Nodule

The Thyroid Nodule: Evaluation, Risk of Malignancy, and Management
Leonard Wartofsky

Fine Needle Aspiration: Technique
Yolanda C. Oertel

Thyroid Nodules: Cellular and Biochemical Markers for Malignancy
Kathleen A. Prendergast

Radionuclide Imaging of Thyroid Nodules
Douglas Van Nostrand

Ultrasonic Imaging of the Neck in Patients with Thyroid Cancer
Manfred Blum

Thyroid Nodules and Cancer Risk: Surgical Management
Orlo H. Clark

Part IV. Well-Differentiated Thyroid Cancer: Papillary Carcinoma

A. Presentation

Papillary Cancer: Clinical Aspects
Leonard Wartofsky

Surgical Approach to Papillary Cancer
Orlo H. Clark

Papillary Carcinoma: Cytology and Pathology
Yolanda C. Oertel and James E. Oertel

Part IV. Well-Differentiated Thyroid Cancer:

B. Initial Management

Prescribed Activity for Radioiodine Ablation
Douglas Van Nostrand

Thyroid Remnant Radioiodine Ablation with Recombinant Human Thyrotropin
R. Michael Tuttle and Richard J. Robbins

Part IV. Well-Differentiated Thyroid Cancer:

C. Surveillance

Follow-Up Strategy in Papillary Thyroid Cancer
Henry B. Burch

Levothyroxine Therapy and Thyrotropin Suppression
Leonard Wartofsky

Thyroglobulin and Thyroglobulin Antibodies: Measurement and Interferences
D. Robert Dufour

Diagnosis of Recurrent Thyroid Cancer in Patients with Positive Antithyroglobulin Antibodies
Matthew D. Ringel

Surveillance Radioiodine Whole-Body Scans
Douglas Van Nostrand

Radionuclide Imaging and Treatment of Thyroid Cancer in Children
Gary L. Francis

Positron Emission Tomography in Well-Differentiated Thyroid Cancer
I. Ross McDougall

Alternative Thyroid Imaging
Anca M. Avram, Karen C. Rosenspire, Stewart C. Davidson, John E. Freitas, and Milton D. Gross

The 'Stunning' Controversy. A. Stunning: Untoward Effect of 13