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Multiple Testing Problems in Pharmaceutical Statistics
ISBN-13:
9781584889854
Veröffentl:
2009
Seiten:
320
Autor:
Alex Dmitrienko
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
0 - No protection
Sprache:
Englisch
Beschreibung:
Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, this volume explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. It describes important multiplicity problems encountered in pre-clinical and clinical trial settings. The book includes numerous case studies from actual pre-clinical experiments and clinical trials to help readers quickly learn common multiple testing methods and apply them to real-life problems. It also reviews relevant regulatory guidelines and implements the methods using SAS and R. The data sets and code are available on the book's website.
Multiplicity Problems in Clinical Trials: A Regulatory Perspective. Multiple Testing Methodology. Multiple Testing in Dose Response Problems. Analysis of Multiple Endpoints in Clinical Trials. Gatekeeping Procedures in Clinical Trials. Adaptive Designs and Confirmatory Hypothesis Testing. Design and Analysis of Microarray Experiments for Pharmacogenomics. Bibliography.
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