Fear grips the Romanian countryside as Vlad Dracula, also known as Vlad the Imapler, a vicious, bloodthirsty prince, vows to return from the dead and drink the blood of the living by the light of the full moon.
Five hundred years later, Brad Tepp, a successful Seattle real estate investor, develops an insatiable craving for blood, so much so, he thinks he may becoming a modern day vampire. All he can think about and dream about is drinking blood. Fearing he is losing his mind, he seeks professional help. After being diagnosed with porphyria, The Disease of Vampires, he is given the prognosis of a year to live. Desperate to find a cure, he searches the internet which leads him to Dr. Nicholas Pitrowski, a Transylvanian geneticist who theorizes that porphyria is an inherited disease which originated with Vlad Dracula. He thinks that if he can find Dracula's remains and clone him, he can isolate the gene responsible for the disease and develop a cure.

The men team up and set off on Halloween night searching for Dracula's remains. The process goes horribly wrong, putting their lives in danger, when they unleash a monster that threatens both themselves and Nadia, a beautiful woman who is key to Brad and Nicholas's success or failure.