During the last few years, exciting new insights into mechanisms and treatment of stroke have been obtained from animal experiments. Hence, the use of animal models to induce stroke are of paramount importance as research tools. While a few articles on this topic have been published in select journals, until now there has not been a systematic tech

¿ Statistical Update of Stroke in America. Rationale for Using Ischemic Stroke Models. Animal Models of Ischemic Stroke: A Historical Survey. Anatomy and Cerebral Circulation of the Rat. Which Animal to Choose? Which Model to Use? Failure Is the Mother of Success: Why Neuroprotective Therapies That Work in Laboratories Fail in Clinical Trials. Anesthesia of Laboratory Rats. General Principles of Microsurgery on Animals. Microsurgical Instruments for Stroke Studies. Postoperative Care. Surgery Procedure for Distal Middle Cerebral Artery Occlusion Model. Surgical Models of Stroke Induced by Intraluminal Filament Implantation. Embolic Stroke Models. Photochemically Based Models of Focal Experimental Thrombotic Stroke in Rodents. Induction of Asphyxia Cardiac Arrest in a Rat as a Model of Global Cerebral Ischemia. Four-Vessel Occlusion Stroke Model in Rats. Brain Hemorrhage Models in Rodents. Endpoints for Stroke Studies. Tissue Staining Techniques for Stroke Studies. Protocol for Brain Vessel Corrosion Casting and Embedding. Magnetic Resonance Imaging in Stroke Study. Administration of Substances and Sampling. Study Design in Animal Models of Stroke. Common Biochemical and Physiological Parameters in Rats.