This volume provides broad coverage of computational and mathematical techniques and concepts related to the field of comparative genomics. The topics covered in the chapters range from those concerned with general techniques and concepts that apply to all organisms to others that are more specialized, covering specific biological systems such as viruses, Drosophila, and Homo sapiens. Written in the highly successful Methods in Molecular Biology series format, by authors who are active researchers in the field, many chapters include step-by-step procedures, which illustrate practical applications of the techniques described.Cutting-edge and thorough, Comparative Genomics: Methods and Protocols should be useful to students and researchers in the continually growing and exciting field of comparative genomics.

Includes cutting-edge methods and protocolsProvides step-by-step detail essential for reproducible resultsContains key notes and implementation advice from the experts

Gene Phyologenies and Orthologous Groups.- Pan-Genome Storage and Analysis Techniques.- Comparative Genomics for Prokaryotes.- Assembly, Annotation and Comparative Genomics in PATRIC, the All Bacterial Bioinformatics Resource Center.- Phylogenomics.- Comparative Genome Annotation.- A Practical Guide for Comparative Genomics of Mobile Genetic Elements in Prokaryotic Genomes.- Comparative Metagenomics.- Genome Rearrangement Analysis: Cut and Join Genome Rearrangements and Gene Cluster Preserving Approaches.- Whole Genome Duplications in Plants; Implications for Evolutionary Analysis.- Sequence-Based Synteny Analysis of Multiple Large Genomes.- Family-Free Genome Comparison.- Comparative Methods for Reconstructing Ancient Genome Organization.- Comparative RNA Genomics.- Bioinformatic Approached for Comparative Analysis of Viruses.- Comparative Genomics of Gene Loss and Gain in Caenorhabditis and Other Nematodes.- Comparative Genomics in Drosophila.- Comparative Genomics in Human.