Practical Process Research and Development - A Guide for Organic Chemists
Practical Process Research and Development - A Guide for Organic Chemists
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ISBN-13:
9781493301256
Veröffentl:
2012
Erscheinungsdatum:
15.04.2012
Seiten:
486
Autor:
Neal G Anderson
Gewicht:
787 g
Format:
228x154x29 mm
Sprache:
Englisch
Beschreibung:
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry."
1. Introduction to the role of process development 2. Process safety3. Route selection 4. Reagent selection5. Solvent selection6. Effects of water7. In-process assays, in-process controls, and specifications8. Practical considerations for scale-up9. Optimizing processes by minimizing impurities10. Optimizing organometallic reactions 11. Workup12. Crystallization and purification13. Final product form and impurities14. Continuous operations 15. Refining the process for simplicity and ruggedness16. Process validation and implementation17. TroubleshootingGlossary and indices: general, reagents, reactions, and drug substances
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