Genetic Variants in Alzheimer's Disease

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This book covers recent research which has identified nine new genes, and the vital realization that new pathways could be involved in the pathogenesis of Alzheimer's. These are now targets for therapeutic intervention, which might one day lead to a cure.
The aim of this book is to put all of the recent genetic data on these new genes into context
The Genetics of Alzheimer's disease: Introduction and Perspective for the Future.- Apolipoprotein E .- Clusterin.- PICALM.- Complement Component (3b/4b) Receptor 1(CR1).- Bridging Integrator 1 (BIN1).- ATP-binding cassette, sub-family A (ABC1), member 7 (ABCA7).- Membrane-spanning 4-domains subfamily A, MS4A cluster.- Sialic acid binding immunoglobulin-like lectin-3 (CD33).- Erythropoietin-producing human hepatocellular carcinoma (EphA1).- CD2-associated protein (CD2AP).- Other Genes Implicated in Alzheimer's Disease.- The Future Role of Biomarkers in Alzheimer's Disease Diagnostics.- Index.
Alzheimer's Disease is the most common form of dementia. The disease is characterised by the loss of synapses and neurons in the cerebral cortex and certain subcortical regions. In the last three years, the genetics of Alzheimer's Disease has made significant advances; in fact, one could argue more than in the previous two decades.  This has resulted in the identification of nine new genes and perhaps more importantly the realization that new pathways could be involved in the pathogenesis of Alzheimer's.  These new pathways are now legitimate targets for therapeutic intervention, which can possibly lead to treatment or a possible cure.  The aim of this book is to put all of the recent genetic data on these new genes into context.  Different genetic variants will be discussed, as well as biomarkers and future possibilities. ¿

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Autor: Minerva M. Carrasquillo
ISBN-13 :: 9781489997999
ISBN: 1489997997
Erscheinungsjahr: 08.07.2015
Verlag: Springer New York
Gewicht: 404g
Seiten: 264
Sprache: Englisch
Auflage 2013
Sonstiges: Taschenbuch, 235x155x14 mm

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