The study of electrophysiology has progressed rapidly because of the precise, delicate, and in- nious experimental studies of many investigators. The ?eld has also made great strides by uni- ingtheseexperimentalobservationsthroughmathematicaldescriptionsbasedonelectromagnetic ?eld theory, electrochemistry, etc. , which underlie these experiments. In turn, these quantitative materialsprovideanunderstandingofmanyelectrophysiologicalapplicationsthrougharelatively small number of fundamental ideas. This text is an introduction to electrophysiology, following a quantitative approach. The ?rst chapter summarizes much of the mathematics required in the following chapters. The second chapter presents a very concise overview of the principles of electrical ?elds and the concomitant current ?ow in conducting media. It utilizes basic principles from the physical sciences and engineering but takes into account the biological applications. The following six chapters are the core material of this text. Chapter 3 includes a description of how voltages/currents exist across membranes and how these are evaluated using the Nernst¿Planck equation. The membrane channels, which are the basis for cell excitability, are described in Chapter 4. An examination of the time course of changes in membrane voltages that produce action potentials are considered in Chapter 5. Propagation of action potentials down ?bers is the subject of Chapter 6, and the response of ?bers to arti?cial stimuli, such as those used in cardiac pacemakers, is treated in Chapter 7. The voltages and currents produced by these active processes in the surrounding extracellular space is described in Chapter 8.

This new edition of the classic introductory text to bioelectricity (electrophysiology) is aimed at biomedical engineering students. It expands on the developments since the successful last edition. The book is authored by two eminent biomedical engineering professors at Duke University who discuss many topics that are central to biophysics and bioengineering and the quantitative methods employed. In addition, this classic text will be complemented by a Bioelectricity Solutions Manual, sure to aid the speed and assimilation of the "Teaching Text" material to the new Biomedical Engineering student. In the first edition of Bioelectricity, Plonsey and Barr provided an introduction to electrophysiology following a quantitative approach. In the second edition they address new discoveries in the field of ion channels and provide an introduction to electrophysiology utilizing a quantitative approach.

Vector Analysis.- Sources and Fields.- Bioelectric Potentials.- Channels.- Action Potentials.- Impulse Propagation.- Electrical Stimulation.- Extracellular Fields.- Cardiac Electrophysiology.- The Neuromuscular Junction.- Skeletal Muscle.- Functional Electrical Stimulation.- Exercises.