This book portrays the commonality of tissue micro-structure that dictates physiological function in various organs (microstructure-function relation). Tissue and organ models are used to illustrate physiological functions based on microstructure. Fiber scale properties such as orientation and crimp are described in detail. Structurally-based constitutive models are given throughout the book, not only to avoid ambiguities in material characterization, but also to offer insights into the function, structure, and mechanics of tissue components. A statement of future directions of the field is also given, including how advancements, such as state-of-the-art computational modeling and optical measurements of tissue/cells structures, are taking structure-based modeling to the next level.  ¿

Chapter 1 The Influence of Microstructure on Neural Tissue Mechanics.- Chapter 2 Modeling a Collagenous Tissues Using Distributed Fiber Orientations.- Chapter 3 Emergent Behaviors in Cell Mechanics.- Chapter 4 Histomechanical Modeling of the Wall of Abdominal Aortic Aneurysm.- Chapter 5 The Biomechanics of Fat: From Tissue to a Cell Scale.- Chapter 6 Glaucoma and Structure-Based Mechanics of the Lamina Cribrosa at Multiple Scales.- Chapter 7 From Stress-Strain Relations to Formulation of Growth and Remodeling Theories: A Historical Reflection on Microstructurally-Motivated Constitutive Relations.- Chapter 8 Relationship Between Structure and Mechanics for Membranous Tissues.- Chapter 9 Structure-Function Relations in the Coronary Vasculature.- Chapter 10 Biomechanical Basis of Myocardium/Vessel Interaction: Implications for Patho-Physiology and Therapy.- Chapter 11 Microstructure-Based Constitutive Models for Coronary Artery Adventitia.- Chapter 12 Structural-Based Models of Ventricular Myocardium.- Chapter 13 Structure-Based Constitutive Model of Coronary Media.- Chapter 14 Biomechanics of the Cornea and Sclera.- Chapter 15 Mechanical Modeling of Skin.- Chapter 16 Undesirable Anisotropy in a Discrete Fiber Bundle Model of Fibrous Tissues.-     Chapter 17 Structural Models as Applied to Engineered Tissue Scaffolds.- Chapter 18 Finite Element Implementation of Structural Models.- Chapter 19 A Microvascular Model in Skeletal Muscle Fascia.- Chapter 20 Network Approaches to the Mechanical Failure of Soft Tissues: Implications for Disease and Tissue Engineering.