Immunobiology of Transfer Factor compiles research papers presented at the Fourth International Transfer Factor Workshop, held at the Given Institute of Pathobiology in Aspen, Colorado, on October 3-6, 1982.This book focuses on the immunologic effects of transfer factor, which are supported by in vitro and in vivo experiments that indicate immunologically specific interactions between transfer factor and antigens. The topics include the selective removal of transfer factor activity with antigen, antigen-specific suppressor factor in human leukocyte dialysates, and specific suppressor dialysates from mice. The kinetics of immune response and production of transfer factor in bovine, dialyzable leukocyte extracts in pulmonary diseases, and mechanisms of action of human transfer factor are also elaborated.This compilation is suitable for microbiologists, immunologists, and specialists researching on transfer factor.

¿ContributorsPrefaceAcknowledgmentsThe Merrill W. Chase Prize in Cellular ImmunologySection I. The Nature of Transfer Factor The Immunological Enigma of Transfer Factor Human Transfer Factor: Specificity and Structural Models Human Transfer Factor: Exogenous Labeling, Purification, and Role of Ribonucleic Acid Segment Selective Removal of Transfer Factor Activity with Antigen Antigen-Specific Inducer Factor in Human Leukocyte Dialysates: A Product of TH Cells which Binds to Anti-V Region and Anti-La Region Antibodies Antigen-Specific Suppressor Factor in Human Leukocyte Dialysates: A Product of Ts Cells which Binds to Anti-V Region and Anti-La Region Antibodies Isolation and Purification of Antigen-Specific Inducer and Suppressor Factors from Pooled Leukocyte Dialysates of Unselected Donors by Affinity AdsorptionSection II. Studies of Dialyzable Leukocyte Extracts in Animals Dialyzable Leukocyte Extract Containing Transfer Factor-Its Future in Veterinary Medicine Effect of Dialyzable Leucocyte Extract and Other Tissue Dialysates on Listeria Resistance Osteosarcoma-Specific Dialyzable Extracts: Prophylaxis Post Surgery in an Animal Model of Human Osteosarcoma Antigen-Specific Transfer Factor Induced in Mice by an Attenuated Virus from the Tick-Borne Encephalitis Complex: Biological, Histological, and Concentration Studies Antigen-Specific Suppressor Factor in Human Leukocyte Dialysates Suppresses in Vivo Footpad Reactivity in Immunized BALB/c Mice Specific Suppressor Dialysates from Mice Kinetics of Immune Response and Production of Transer Factor in Bovine Transfer of Cell-Mediated Immunity in Vitro to Human Lymphocytes Using Dialyzable Leukocyte Extracts from Immune BurrosSection III. Studies of Dialyzable Leukocyte Extracts in ManThe Use of Antigen Specific Transfer Factor in the Management of Infections with Herpes Viruses Specific Bovine Transfer Factor for the Treatment of Herpes Infections Oral Bovine Transfer Factor (OTF) Use in the Hyper-IgE Syndrome Dialyzable Leukocyte Extracts in Pulmonary Diseases (Lung Cancer and Recurrent Bronchitis) Clinical Use of Leukocyte Dialysate (Transfer Factor) in Osaka Area of Japan Clinical Applications of the Leukocyte Migration Inhibition Assay-New Methods for Determining Transfer Factor Potency and for Predicting Clinical Response The Effects of Immune and Nonimmune Dialyzable Leucocyte Extracts on KLH and HCH Reactivity in Unprimed Human Recipients: A Double Blind StudySection IV. In Vitro Activities in Dialyzable Leukocyte Extracts Mechanism(s) of Action of Human Transfer Factor: Insights Obtained from Studying "Antigen-Liberated Transfer Factor" Specific for Tuberculin Dialyzable Leukocytes Extracts (D.L.E.) and Theophylline-Treated Lymphocytes Dialyzable Leucocyte Extract Stimulates cAMP in ¿¿ Lymphocytes: Lack of Fc-Receptor Induction or NK-Cell Activation Porcine Spleen Cell Dialysate Increases the Phagocytic Capacity and Decreases Prostaglandin Levels of Peritoneal Macrophages in Mouse Initial Characterization of an Ampliative Nucleoside Isolated from Human Dialyzable Leukocyte Lysate Immunochemical and Physical-Chemical Evidence for the Presence of Thymosin AlpharPeptide in Dialyzable Leukocyte Extracts Thymosin a1-Like Material in Dialy sates of Leukocyte Extracts Transfer Factor and Immune RNAClosing CommentsIndex