The Role of Products of the Histocompatibility Gene Complex in Immune Responses documents the proceedings of a conference held on 3-7 November 1975, which brought together an international group of scientists spanning three independent disciplines-genetics and immunogenetics, molecular biochemistry, and immunobiology-with clinical medicine overlapping these disciplines. This volume contains 42 papers organized according to the eight sessions held at the conference. The papers in Session I examined the genetics of the major histocompatibility complex. Session II presented studies on the biology of mixed lymphocyte interactions and cell-mediated cytotoxicity reactions. Session III discussed immune response gene systems while Session IV dealt with the genetic control of cell interactions. The papers in Session V covered idiotypic determinants on T cell receptors. Session VI investigated the properties of histocompatibility gene products involved in regulation of immune responses. Session VII focused on the biochemistry and immunocytology of cell surface products of the major histocompatibility complex. Finally, Session VIII discussed interrelationships between products of the major histocompatibility complex and their relevance to disease.

ParticipantsPrefacePhotographs of ParticipantsSession 1: Genetics of the Major Histocompatibility Complex Genetic Resolution of the Products and Functions of I and S Region Genes of the Mouse H-2 Complex Discussion following Donald Shreffler The Genetics of the Major Histocompatibility Complex in Man, HLA Discussion following Jon van Rood Molecular Relationships of Ia Antigens Controlled by the Same and by Different Subregions of the I Region Br and Wh, B Cell Antigens in Gluten Sensitive Enteropathy and Dermatitis Herpetiformis Recent Studies of Ia like Antigens and Complement Components Relating to the Human Histocompatibility System Natural Killer Cells in the Mouse Evidence for the Association of Specificity Ia. 3 with an I-A Region Molecule General Discussion - SessionSession II: The Biology of Mixed Lymphocyte Interactions and Cell-Mediated Cytotoxicity Reactions Genetic and Cellular Aspects of Mixed Leukocyte Culture and Cell Mediated Lympholysis Reactions Discussion following Fritz Bach Bifunctional Histocompatibility-Linked Regulation of Cell Mediated Lympholysis to Modified Autologous Cell Surface Components Discussion following Gene Shearer The Role of Ia Antigens in MLC Stimulation H-2 Associated MLR Determinants: Immunogenetics of the Loci and Their Products Responses of Alloantigen Reactive Lymphocytes to Conventional Antigens Evidence for Several Closely Linked Genes Involved in Generation of Proliferation in MLC Suppressive Interactions between Different MLR Loci Does the Apparent H-2 Compatibility Requirement for Virus-Specific T Cell-Mediated Cytolysis Reflect T Cell Specificity for "Altered Self" or Physiological Interaction Mechanisms? General Discussion - SessionSession III: Immune Response (Ir) Gene Systems The Nature and Function of Specific H-Linked Immune Response Genes and Immune Suppression Genes Discussion following Baruj Benacerraf Functional Analysis of Ia Antigens in Relation to Genetic Control of the Immune Response Discussion following Hugh McDevitt H-2 Linked Immune Response Genes: Multiplicity and Functional Complementation H-3-Linked Unresponsiveness to EA-1 and H-13 Antigens Immune Responses of Mice against Modified Random Polymers of Amino Acids, and Implications in Gene Control A Possible Function for Products of the Major Histocompatibility Complex in Humoral Immunity General Discussion - SessionSession IV: Genetic Control of Cell Interactions Macrophage-T Lymphocyte Interaction: The Cellular Basis for Genetic Control of Antigen Recognition Discussion following Alan Rosenthal Genetic Control of Lymphocyte Interactions and Differentiation Discussion following David Katz Stimulation of Antibody Responses In Vitro by Antigen-Bearing Syngeneic and Allogeneic Macrophages H-2 Linked Ir Gene Regulation of Delayed-Type Hypersensitivity in Mice Differential Expression of Ia Antigens on Suppressor T Cells, Helper T Cells, and B Precursor Cells Effective Allogeneic T Cell-B Cell Interaction in Chimeric Mice General Discussion - SessionSession V: Idiotypic Determinants on T Cell Receptors T Lymphocyte Receptor Analysis by Anti-Idiotypic Stimulation Discussion following Klaus Rajewsky Idiotypic Receptors for Antigen on T Lymphocytes Discussion following Hans WigzellSession VI: Properties of Histocompatibility Gene Products Involved in Regulation of Immune Responses The Nature of Antigen Specific T Cell Factors Involved in the Genetic Regulation of Immune Responses Discussion following Edna Mozes Characterization of the Antigen-Specific Suppressive T Cell Factor with Special Reference to the Expression of I Region Genes Discussion following Tomio Tada Histocompatibility Gene Products as Mediators of Lymphocyte Interactions I-Region Gene Products in Cell Cooperation Suppressive Activity of Lymphoid Cell Extracts from Non-Responder Mice Injected with the Terpolymer L-Glutamic Acid60-L-Alanine30-L-Tyrosine10 (GAT) Anti-ß2 Microglobulin - a Selective PBA for Human and Mouse B Lymphocytes General Discussion - SessionSession VII: Biochemistry and Immunocytology of Cell Surface Products of the Major Histocompatibility Complex Cytological Analysis of Histocompatibility Molecules Discussion following Emil Unanue Isolation and Structure of Products of the Human Histocompatibility Gene Complex Discussion following Jack Strominger Studies on the Chemical Basis of Variability and the Complex Cellular Expression of the H-2K and H-2D Products Discussion following Stanley Nathenson Structure and Biological Activity of H-2 Antigens Genetic and Evolutionary Implications of the Partial Amino Acid Sequences of H-2K and H-2D Alloantigens The Chemistry of Mouse and Guinea Pig Ia Antigens General Discussion - SessionSession VIII: Interrelationships between Products of the Major Histocompatibility Complex and Their Relevance to Disease General Discussion 1a) Specificity of H-Linked Ir Gene Function 1b) Microheterogeneity of Ia Molecules 2) Evidence for Existence of a Distinct 1-B Sub-Region 3a, b, c) Nature of the Antigen Receptor on T Cell Factors and Relationship to vH Regions and Ig Idiotypes; Their Specificity Range as Compared to Immunoglobulins; and Possible Existence of Dual Recognition Systems at the T Cell Level and at Other Levels 4) Similarities and Differences between Helper and Suppressor Factors 5) Basis for the Large Numbers of Allospecific T Cells Recognizing MHC Antigens 6) The Phenomenon of Cis-Trans Preference in Complementation of Ir Genes and Its Relevance to Linkage Disequilibrium in MHC 7) The Basis for Presence or Absence of Genetic Restrictions in T-B Cell Cooperation - Adaptation or Selection? Relationship of the MHC to Disease