Animal Virus Genetics is a collection of scientific presentations of the ICN-UCLA Symposia on Molecular and Cellular Biology, held at the University of California, Los Angeles in 1980.The papers in the compendium focus on the basic genetic model systems; the uses of genetic approaches to study basic problems in molecular biology; and on the increasing application of genetic systems to the study of more complex viral-host interactions such as viral virulence and persistence. Microbiologists, cellular biologists, and virologists will find the book insightful.

ContributorsPrefaceI. Procaryotic Models 1 IS-Elements and Transposons 2 A Modular Theory of Virus EvolutionII. Genome Structure and Organization 3 Molecular Cloning of the Human Cytomegalovirus Genome (Strain AD 169) 4 Structural Organization of the DNA Molecules from Human Cytomegalovirus 5 The Nucleotide Sequence of the Hepatitus B Viral Genome and the Identification of the Major Viral Genes 6 Correlating Genetic Mutations of a Baculovirus with the Physical Map of the DNA Genome 7 Analysis of VSV Glycoprotein Structure and Genome Structure Using Cloned DNA 8 Ribosome Binding to Polio Virus RNA 9 Sequence Analysis of the Poliovirus Genome and Mapping of the Genome-Linked Protein 10 Reovirus Genome RNA: Common 3'-Terminal Nucleotide Sequences and Assignment of mRNA Ribosome Binding Sites to Virion Genome Segments 11 Terminal Sequence Homologies in Reovirus GenesIII. Cellular Genes 12 Attempts at the Molecular Cloning of a Transforming Allele from Chemically Transformed Mouse Cells 13 Mechanisms of DNA-Mediated Transformation in Animal Cells 14 Chromosomal Mapping of Ecotropic and Xenotropic Leukemia Virus-Inducing Loci in the Mouse 15 Correlation between the Development of Murine Mammary Cancer and the Segregation of Endogenous Genes 16 A Study of the Endogenous Moloney-Related Sequences of Mice 17 Structural and Genetic Relationships between an Endogenous Retrovirus (M432) of Mus cervicolor and Intracisternal A-Particles of Mus musculus 18 Genetic Control of MuLV Expression and Spontaneous Lymphoma in Crosses of High- and Low-Lymphoma Strains 19 The Anomalous Antibody Response of Hybrid Mice to Immunization with an Abelson Virus Lymphoma 20 AKvr-1, A Dominant Murine Leukemia Virus Restriction Gene, Segregates in Leukemia-Prone Wild Mice 21 Genetic Control of Resistance of Mouse Hepatitis Virus, Strain JHM, Induced EncephalomyelitisIV. Integration 22 Learning about the Replication of Retroviruses from a Single Cloned Provirus of Mouse Mammary Tumor Virus 23 Observations on the DNA Sequence of the Extended Terminal Redundancy and Adjacent Host Sequences for Integrated Mouse Mammary Tumor Virus 24 Derivation of Three Mouse Strains Carrying Moloney Leukemia Virus in Their Germ Line at Different Genetic Loci 25 A Human Hepatoma Cell Line Contains Hepatitis B DNA and RNA SequencesV. Regulation and Expression 26 Polyoma Virus HR-T Gene Products 27 Complementation Studies with Transformation Defective Mutants of Polyoma Virus 28 Analysis of Adenovirus-Induced Cellular DNA Synthesis in a ts Mutant of the Cell Cycle 29 Regulation of Adenovirus Early Gene Expression 30 Methylation and Expression of Adenoviral DNA in Infected and Transformed Cells 31 Synthesis of Adenovirus 2 RNA in vitro: Properties of the Major Late Transcript and Its Promoter 32 A Gene Function of Herpes Simplex Virus Required for Expression of All Early Viral Genes 33 A Variant VSV Generates Defective Interfering Particles with Replicase-like Activity in vitro 34 Separation of Full Length Transcripts and Genome RNA Plus and Minus Strands from Cytoplasmic Polyhedrosis Virus of Bombyx mori 35 Differential Methylation of Endogenous and Acquired Mouse Mammary Tumor Virus-Specific DNA 36 SFFV Specific Gene Expression in Infected and Erythroleukemia Cells 37 Molecular Genetics and Cell Culture Assays for Helper-Independent and Replication-Defective Components of the Friend Virus Complex 38 Viral Envelope Genes and c Regions in Non-acute Avian Leukosis Virus-Associated DiseaseVI. Transformation 39 Two Regions of the Moloney Leukemia Virus Genome Are Required for Efficient Transformation by src/sarc 40 Molecular Cloning of Moloney Mouse Sarcoma Virus Specific Sequences from Uninfected Mouse Cells 41 Characterization of Molecularly Cloned Spleen Focus-Forming Virus DNA 42 The Nature and Origin of the Transforming Gene of Avian Sarcoma Viruses 43 Phosphorylation of Tyrosine: A Mechanism of Transformation Shared by a Number of Otherwise Unrelated RNA Tumor Viruses 44 PRCII, A New Type of Avian Sarcoma Virus 45 Fujinami Sarcoma Virus and Sarcomagenic, Avian Acute Leukemia Viruses Have Similar Genetic Structures 46 A Model for Focma Expression in Cells Transformed by Feline Leukemia and Sarcoma Viruses 47 Transformation-Defective Mutants of AEV and MC29 Avian Leukemia Viruses Synthesize Smaller gag-Related Proteins 48 Isolation and Characterization of Phenotypic Revertants from Moloney Murine Sarcoma Virus-Transformed CellsVII. Viral Gene Products and Assembly 49 Genetics of Acycloguanosine Resistance and the Thymidine Kinase Gene in HSV-1 50 Study of Genetic Variability of Viruses through the Use of Monoclonal Antibodies 51 Vesicular Stomatitis Virus Morphogenesis Is Accompanied by Covalent Protein Modifications 52 Uncoupling of the Hemagglutinating and Neuraminidase Activities of Newcastle Disease Virus (NDV) 53 Suppression of Temperature-Sensitive Phenotype in Reovirus: An Alternate Pathway from ts to ts+ Phenotype 54 Translation Products of the 124 Strain of Moloney Murine Sarcoma Virus (Mo-MuSV): Characterization of a 23,000 Dalton Candidate 'src' Gene Product 55 Characterization and Genetic Analysis of Retrovirus Maturation: A Role for Pr180gag-palVIII. Viral Virulence and Persistence 56 The Molecular Basis of Reovirus Virulence 57 A Genetic Approach to Cytopathogenicity, Virus Spread, and Virulence of Newcastle Disease Virus (NDV) 58 In Vitro Selection of An Attenuated Variant of Sindbis Virus 59 Viral Mutation in Persistent Infection 60 Antigenic Variation of Visna Virus 61 Possible Mechanism of Rotavirus Persistence 62 Neurovirulence and Persistency of Mouse Hepatitis Viruses in Rats 63 Persistent Infections of Bunyaviruses in Aedes albopictus 64 Experimental Relapsing Myelitis in Hamsters Associated with a Variant of Measles Virus 65 Antibody-Induced Modulation of Viral Antigens from Infected Cells: Biological and Molecular Studies of Measles Virus Infection and Implications for Understanding Virus Persistence and Receptor DiseasesIX. Workshops 66 Herpes and Pox Virus 67 Adenovirus/SV40/Polyoma I 68 Adenoviruses/SV40/Polyoma II 69 Picornaviruses/Togaviruses/Hepatitis/Coronaviruses 70 Rhabdoviruses and Paramyxoviruses 71 Segmented RNA Viruses 72 Cell Genes and Viral Transformation 73 Immunogenetics of Animal VirusesIndex