Methods of Animal Experimentation, Volume VII: Research Surgery and Care of the Research Animal, Part A is a collection of papers that deals with methods used in animal experiments involving patient care, vascular access, and telemetry. This book concerns technologies in experimental surgery - complicated procedures requiring longer observation time of the test animal, and an increase in the spectrum of animals that can be used. One paper describes the anesthesia, analgesia, and kinds of restraints that are suited for the test animal. A wide array of choices of inhalational agents, injectable, local anesthesia (lidocaine), analgesics (opioids and aspirin), and restraint (nonanesthesia and neuromuscular-blocking agents) is available for the researcher to choose from. Several authors also describe the use of telemetry devices that are implantable in test animals to achieve minimal interference from the investigator. These devices include sensors such as flow transducers and probes to use in pulse or continuous wave-applications; electromagnetic flowmeters for blood monitoring; and integrated circuits for various applications. One paper discusses postoperative care including a patient care checklist, treatment of common postoperative complications, as well as venous catheters for fluid administration. This text will be appreciated by veterinarians, technicians dealing with laboratory animals, and researchers designing animal and medical experiments.

ForewordPrefaceChapter 1 Anesthesia, Analgesia, and Restraint I. Introduction II. General Anesthesia: Inhalation Agents III. General Anesthesia: Agents Given by Other Than the Inhalational Route IV. Local Anesthesia V. Analgesia VI. Restraint VII. Application Notes VIII. Concluding Comments Appendix I: Sources of Equipment, Supplies, and Drugs Appendix II: Drug Schedules per Controlled Substance Act of 1970 (U.S.A.) ReferenceChapter 2 Implantable Telemetry I. Introduction II. Applications III. Sensors IV. Systems V. Integrated Circuits VI. Implant Technology VII. External Electronics Used with Implantable Telemetry References Chapter 3 Postoperative Care I. Introduction II. Postoperative Patient Care Checklist III. Causes and Treatments of Common Postoperative Complications IV. Introduction and Maintenance of Indwelling Venous Catheters for Fluid Administration ReferencesChapter 4 Indwelling Vascular Cannulas for Remote Blood Sampling, Infusion, and Long-Term Instrumentation of Small Laboratory Animals I. Introduction II. Selection of Materials for Intravascular Catheters III. Design of Experiments Requiring Blood Sampling and Intravascular Access IV. Physiological Constraints Imposed by Small Body Mass V. Blood Sampling and Injection of Animals without Cannulas VI. Surgical Techniques for Intravascular Cannulation VII. Blood Sampling and Infusion from Intravascular Cannulas VIII. Remote Access Intravascular Cannulas IX. Implantable Infusion Pumps X. Overview and Conclusions ReferencesChapter 5 Vascular Access in Large Laboratory Animals I. Introduction II. General Considerations III. Methods of Blood Access IV. Factors Influencing Animal Selection V. Conclusion ReferencesIndex