Advances in Lipid Research, Volume 3 presents the analysis of human serum lipoproteins and emphasizes the possibilities inherent in the application of computer methods to such analyses. This book discusses the effects of various drugs on the other important component of the serum lipids, the phospholipids.Organized into six chapters, this volume begins with an overview of the possibility of a dehydrogenation toward the methyl group. This text then presents a detailed discussion of lipoprotein structure, metabolism, and catabolism. Other chapters consider some potentially significant revisions in lipoprotein procedure, including additions to the technology of lipoprotein analysis. This book discusses as well the chemistry and metabolism of plasma lipoprotein as related to physiological and disease states. The final chapter deals with the advances in methods of purification and studies of the properties and mode of action of lipases.This book is a valuable resource for organic chemists, neurochemists, and biochemists.

Contributors to this VolumePrefaceThe Metabolism of Polyenoic Fatty Acids I. The Transformation of Oleic Acid into ¿5,8,11-C20-Trienoic Acid II. The Inconvertibility of One Type of Polyenoic Acid into Another III. The Behavior of the Isomers of Linoleic and Linolenic Acids IV. The Combustibility of the Polyenoic Acids Addendum: Preparation by Total Synthesis of Unsaturated, Especially Polyenoic, Fatty Acids ReferencesThe Analysis of Human Serum Lipoprotein Distributions I. Introduction and General Considerations of Human Serum Lipoprotein Analysis II. Some Unique Problems of Ultracentrifugal Lipoprotein Isolation and Flotation Analysis III. A Generalized Method for the Computer Analysis of Lipoprotein Distributions IV. Application of Computer Analysis to a Series of Adult Normal Males and Females V. Potential Improvements in the Computer Methodology for Lipoprotein Analysis ReferencesFactors Affecting Lipoprotein Metabolism I. Introduction II. Physical and Chemical Properties of Plasma Lipoproteins III. Experimental Approach to Lipoprotein Structure IV. Biosynthesis of Plasma Lipoproteins V. Catabolism of Plasma Lipoproteins VI. Significance of Lipoproteins in Fat Transport VII. Concluding Remarks ReferencesThe Action of Drugs on Phospholipid Metabolism I. Introduction II. Excitants and Antidepressants III. Depressants IV. Glycosides V. Pharmacologically Active Phospholipids ReferencesBrain Sterol Metabolism I. Introduction II. Distribution of Sterols in the Developing Brain III. Distribution of Cholesterol in the Adult Mammalian Brain IV. Brain Cholesterol Metabolism V. Brain Sterols: The Effects of Drugs VI. Brain Cholesterol: The Effects of Malnutrition VII. Brain Sterols: The Effects of Disease VIII. Conclusion ReferencesLipases I. Introduction II. Distribution of Lipases III. Methods of Determining Lipase Activity IV. Purification V. Substrate Specificity and Mode of Action VI. Factors Affecting the Velocity of Hydrolysis VII. Lipoprotein Lipase VIII. Summary ReferencesAuthor IndexSubject Index