Current Topics in Cellular Regulation, Volume 20 evaluates the basic mechanisms involved in the regulation of diverse cellular activities.This book discusses the role of glutamine in the flow of nitrogen, regulation of glycogen synthase activity by covalent phosphorylation, and physiological role of PFK phosphorylation. The in vivo modulation of HMG-CoA reductase activity, hypotheses on the role of eIF-2 phosphorylation, and ADP-ribosyltransferase from turkey erythrocytes are also elaborated. This text likewise covers the non-enzymic effects of vanadate and phosphorylation of liver and muscle PFK.This volume is a good source for biologists and researchers interested in advances in the general area of cellular regulation.

List of ContributorsGlutamine Metabolism in Higher Plants I. Introduction II. Enzymes of Glutamine Metabolism III. The Role of Glutamine in the Flow of Nitrogen ReferencesGlycogen Synthase and Glycogen Synthase Kinases I. Introduction II. Glycogen Synthase III. Glycogen Synthase Kinases IV. Multiple Phosphorylation of Glycogen Synthase and Its Effect on Enzymic Properties V. Regulation of Glycogen Synthase Activity by Covalent Phosphorylation VI. Conclusion References Note Added in ProofCovalent Modification of Phosphofructokinase by Phosphorylation-Dephosphorylation I. Introduction II. Phosphorylation of Liver and Muscle PFK III. The PFK-Inactivating Enzyme IV The Physiological Role of PFK Phosphorylation References Note Added in ProofRegulation of Liver 3-Hydroxy-3-Methylglutaryl-CoA Reductase I. Background II. Rat Liver Microsomal HMG-CoA Reductase III. In Vitro Modulation of HMG-CoA Reductase Activity by Covalent Modification IV. Characterization and in Vitro Modulation of Reductase Kinase V. In Vivo Modulation of HMG-CoA Reductase Activity VI. In Vivo Modulation of Reductase Kinase Activity VII. In Vivo Modulation of the Enzymic Activity and Degree of Phosphorylation of HMG-CoA Reductase VIII. Bicyclic Cascade of HMG-CoA Reductase and Its Comparison with the Cascade Systems of Glycogen Phosphorylase and Glutamine Synthetase IX. Current Model for in Vivo Regulation of Cholesterol Biosynthesis X. Summary ReferencesPhosphorylation Reactions That Influence the Activity of eIF-2 I. Introduction II. Phosphorylation of eIF-2a III. Phosphorylation of eIF-2ß IV. Hypotheses on the Role of eIF-2 Phosphorylation ReferencesMono(ADP-Ribosyl)Transferases and Their Effects on Cellular Metabolism I. Introduction II. Inhibition of Protein Synthesis by Diphtheria Toxin and Pseudomonas Exotoxin A III. Activation of Adenylate Cyclase by Choleragen and Escherichia coli Heat-Labile Enterotoxin IV ADP-Ribosylation of RNA Polymerase in Phage-Infected Escherichia coli V. ADP-Ribosyltransferase from Turkey Erythrocytes VI. Summary and Perspectives ReferencesDoes Vanadium Play a Role in Cellular Regulation? I. Introduction II. Physiological Effects III. Metabolic Effects IV. Effects on Enzyme Activities V. ATPases VI. Adenyl Cyclase VII. NADH Oxidase VIII. Transport and Intracellular Distribution IX. Nonenzymic Effects of Vanadate X. Concluding Remarks ReferencesIndexContents of Previous Volumes