Advances in Behavioral Pharmacology, Volume 3 covers papers dealing with various aspects of the ways in which drug effects are related to and perhaps modified by the rate of responding. The book discusses the behavioral actions of benzodiazepines and considers the extent to which these actions are consistent with the proposition that these effects are partially or entirely determined by control rates of responding. The text then describes rate-dependence and the effects of phenothiazine antipsychotics in pigeons; the rate-convergent effects of drugs; and the rate-dependent effects of extra stimuli, of drugs, and drug-state change. Historical, mathematical and alternative considerations in quantitation in behavioral pharmacology, as well as the history and status of rate-dependency investigations are also considered. The book then tackles the scope and limitations in the explanation and analysis of the behavioral effects of drugs; drug effects on behaviors maintained by different events; and the importance of identifying which of these factors contributes to the behavior studied in any given experiment. Pharmacologists, psychologists, psychiatrists, and students taking these disciplines will find the book useful.

List of ContributorsPrefacePreface to the Ottawa Conference on the Rate-Dependent Effects of DrugsContents of Previous VolumesRate-Dependence and the Effects of Benzodiazepines I. Introduction II. Effects of Benzodiazepines on Overall Rates of Responding Maintained by Different Schedules of Reinforcement III. Effects of Benzodiazepines on Local Response Rates on Fixed-Interval Schedules IV. Effects of Benzodiazepines on Punished Responding V. Conclusions ReferencesRate-Dependence and the Effects of Phenothiazine Antipsychotics in Pigeons I. Introduction II. Effects of Phenothiazines on Multiple Fixed-Ratio, Fixed-Interval Performances III. Effects of Phenothiazines on Shock-Avoidance Responding IV. Effects of Phenothiazines on the Stimulus Control of Responding V. Conclusions ReferencesRate-Convergent Effects of Drugs I. Introduction: Rate-Dependency II. Questions about Rate-Dependency III. Problem: The Definition of Drug Effect IV. Distributions of Rate-Dependency Slopes V. Convergence of Rates VI. Conclusions ReferencesRate-Dependency: A Nonspecific Behavioral Effect of Drugs I. Introduction II. Rate-Dependent Effects of Extra Stimuli III. Rate-Dependent Effects of Drugs and Drug-State Change IV. Duration of Rate-Dependent Changes Produced by Drugs and Stimuli V. Effects of Varying the Intensity of ES and Dosage of Drug VI. Type of Behavior Affected by Drugs and ES VII. Conclusion ReferencesQuantitation in Behavioral Pharmacology I. Introduction II. Historical Considerations III. Mathematical Considerations IV. Alternative Considerations V. Conclusions ReferencesRate-Dependency: Scope and Limitations in the Explanation and Analysis of the Behavioral Effects of Drugs I. Introduction II. Response Rate and Other Influences on the Behavioral Effects of Drugs III. Usefulness of Rate Analyses in Understanding the Actions of Drugs IV. What Gets Changed When a Drug Alters Response Rates? V. Conceptual Status of the Rate-Dependency Principle VI. Conclusions ReferencesHistory and Present Status of Rate-Dependency Investigations Text ReferencesDrug Effects on Behaviors Maintained by Different Events I. Introduction II. Early Studies III. Characteristics of Behaviors Maintained by Different Events IV. Comparisons of Drug Effects on Responding Maintained by Different Events V. Summary and Conclusions ReferencesOral Self-Administration and the Relevance of Conditioned Taste Aversions I. Introduction II. Factors Maintaining Oral Self-Administration III. Oral Self-Administration of Opioids IV. Conditioned Taste Aversions Produced by Naloxone V. Conditioned Taste Aversions Produced by Self-Administered Drugs VI. Factors Influencing Amphetamine-Produced Taste Aversions VII. Influence of Conditioned Taste Aversions on Operant Behavior VIII. A Pharmacological Approach to Conditioned Taste Aversion IX. Conditioned Anorexia Hypothesis of Taste Aversion X. Duration of Drug Action and Conditioned Taste Aversion XI. Summary and Conclusions ReferencesIndex