Textbook of Medical Virology presents a critical review of general principles in the field of medical virology. It discusses the description and molecular structures of virus. It addresses the morphology and classifications of viruses. It also demonstrates the principal aspects of virus particle structure. Some of the topics covered in the book are the symmetrical arrangements of viruses; introduction to different families of animal viruses; biochemistry of virus particles; the immunological properties and biological activities of viral gene products; description of enzymatic activities of viruses; and haemagglutination, cell fusion, and haemolysis of viruses. The description and characteristics of viral antigens are covered. The identification and propagation of viruses in tissue and cell cultures are discussed. An in-depth analysis of the principles of virus replication is provided. A study of the morphogenesis of virions is also presented. A chapter is devoted to virus-induced changes of cell structures and functions. The book can provide useful information to virologists, microbiologists, students, and researchers.

1 Viruses - A Unique Kind of Infectious Agent 2 The Morphology of Virus Particles. Classification of Viruses Infectious Nucleic Acid Principal Aspects of Virus Particle Structure Live or Dead Materia? Structural Proteins - Symmetry Arrangements The Virus Envelope Classification of Viruses Introduction to Different Families of Animal Viruses3 The Biochemistry of Virus Particles Virus-DNA Virus-RNA Virus Proteins Additional Components in Virions4 Viral Gene Products; Their Immunological Properties and Biological Activities Viral Antigens Haemagglutination Cell Fusion and Haemolysis Enzymatic Activities of Viral Gene Products 5 Cultivation of Viruses Identification and Propagation of Viruses in Tissue and Cell Cultures Identification and Propagation of Viruses in Embryonated Hen's Eggs Identification and Cultivation of Viruses in Experimental Animals 6 General Views on Virus Replication Morphological Methods for Analysis of Virus Replication Molecular Methods for Characterization of Virus Replication Quantitative Determination of Virus Infectivity Quantitative Determination of Other Biological Properties of Viral Products The Different Phases of Virus Replication 7 Attachment of Viruses to Cell Receptors and Penetration of Viruses Into Cells Virus and Receptors Penetration8 Replication, Transcription and Translation of RNA Viruses Classes of RNA Viruses Reoviruses Picornaviruses Togaviruses Rhabdoviruses and Paramyxoviruses Orthomyxoviruses Retroviruses 9 Replication, Transcription and Translation of DNA Viruses Parvoviruses Papovaviruses Adenoviruses Herpesviruses Poxviruses 10 The Morphogenesis of Virions The Maturation and Release of Non-Enveloped Viruses The Morphogenesis of Enveloped Viruses 11 Virus-Induced Changes of Cell Structures and Functions Cytopathic Changes Inclusions in Virus-Infected Cells The Effect of Integration of Viral Antigens in Cellular Membranes Effects of Viruses on Functions of Highly Specialized Cells Chromosomal Changes Virus-Induced Cell Transformation Interferon 12 Virus Genetics Mutations Recombination Phenotypic Mixing and Complementation13 General Aspects of Pathogenesis of Virus Infections Modes of Transmission of Virus Diseases The Importance of Cellular and Viral Receptor Functions The Spread of Virus Infections within The Body The Importance of Barrier Systems in Limiting the Spread of the Infection Influence of Immune Reactions On The Pathogenesis Influence of Constitution, Age, Sex and Genetic Background 14 Pathogenesis of Acute Virus Infections Respiratory Infections Infections of Visceral Organs Infections of the Skin and Mucous Membranes Infections of the Nervous System 15 The Pathogenesis of Congenital Infections Different Ways by Which a Virus May Cause Fetal Damage Spread of Virus in Congenital Infections Direct Effects of Fetal Infections Indirect Fetal-Damaging Effects in Connection with Infections of Pregnant Women 16 The Pathogenesis of Persistent Infections Chronic Subclinical Infections with Immune Pathological Reactions Latent Infections Slow Virus Infections Caused by Conventional Viruses17 Slow Infections Caused by Non-Immunogenic Infectious Agents Different Forms of Infectious Encephalopathy Biological and Physical-Chemical Properties of Atypical Infectious Agents How do Atypical Infectious Agents Spread? 18 Viruses and Tumors Tumor Viruses in Animals Human Tumor Viruses Human Tumor Virus Candidates 19 Mechanisms of Defense Against Virus Infections Non-Specific Immunity Humoral Immunity Cell-Mediated Immunity Immunopathological Effects of Virus Infections Virus Infections in Connection with Malignant Diseases and Immune Suppression Immunological Defense Against Congenital Virus Infections 20 Laboratory Techniques for Diagnosis of Virus Infections Isolation of Viruses Direct Identification of Virus or Viral Antigens in Samples from Patients Analysis of Antibody Response In Patients Evaluation of Laboratory Results 21 The Epidemiology of Virus Diseases Methods of Surveillance of the Epidemiological Occurrence of Infectious Diseases The Dissemination Mechanisms of Virus Infections Epidemiological Patterns of Virus Infections Examples of the Epidemiology of Some Virus Diseases 22 Inactivation of Viral Infectivity and Disinfection 23 Immune Prophylaxis Passive Immunization Active Immunization24 Antiviral Drugs Mechanisms of Action of Antiviral Drugs Antiviral Drugs Used for Clinical Chemotherapy Antiviral Drugs with a Potential Clinical Usefulness Interferon 25 Picornaviruses Properties of Picornaviruses Enteroviruses Rhinoviruses 26 Togaviruses Alphaviruses Flaviviruses Rubellavirus (Rubivirus)27 Orthomyxoviruses (Influenza Viruses) Properties of the Virus Clinical Features Pathogenesis Epidemiology Laboratory Diagnosis Prophylaxis 28 Paramyxoviruses Parainfluenza Virus Mumps Virus Measles Virus Respiratory Syncytial (RS) Virus29 Adenoviruses Properties of the Virus Clinical Features Epidemiology Prophylaxis30 Hepatitis Viruses Properties of the Virus Clinical Features Pathogenesis Immunity Laboratory Diagnosis Epidemiology Prophylaxis 31 Herpesviruses Properties of the Virus Latency and Transformation Herpes Simplex Virus (HSV) Infections Varicella Zoster Virus (VZV) Infections Cytomegalovirus (CMV) Infections Epstein-Barr Virus (EBV) Infections 32 Poxviruses Classification Properties of the Virus Variola (Smallpox) Smallpox Vaccine (Vaccinia Virus) The WHO Smallpox Eradication Program Clinical Features of Variola Laboratory Diagnosis Other Medically Important Poxviruses 33 Other Viruses Reoviruses Retroviruses Bunyaviruses Arenaviruses Coronaviruses Rhabdoviruses (Rabies Virus) Marburg/Ebola Virus Parvoviruses Papovaviruses 34 Viral Syndromes Respiratory Tract Infections Infections of the Pharynx Infections with Exanthemas Hepatitis Gastrointestinal Infections Urogenital Infections Infections of the Nervous System Infections of the Sensory Organs Neonatal Infections Appendix. Chlamydia Microbiology of Chlamydiae Chlamydia Psittaci Infections Chlamydia Trachomatis Infections Laboratory Diagnosis Susceptibility of Chlamydiae to Antibiotics Index