Hormonal Steroids contains the plenary and symposium lectures delivered to the Fifth International Congress on Hormonal Steroids held at New Delhi on October 30 to November 4, 1978. The plenary lectures include biochemical actions of trophic hormones and steroids on steroid production and spermatogenesis in testes; chemical reactions of steroids which imitate the selectivity of enzymatic transformations; and human chorionic gonadotrophin and ovarian and placental steroidogenesis. Symposia papers comprise of water-soluble steroidal anesthetics; quality control of radioimmunoassay of hormones in reproductive physiology; automation of steroid radioimmunoassay for clinical and research purposes; non-radioisotopic homogeneous steroid immunoassays; mechanisms involved in the regulation of steroid receptor levels; and metabolic effects of corticosteroid therapy in post-menopausal women.

ContentsPlenary Lectures Gregory Pincus and Steroidal Contraception: A New Departure in the History of Mankind The Testes: Biochemical Actions of Trophic Hormones and Steroidson Steroid Production and Spermatogenesis Chemical Reactions of Steroids Which Imitate The Selectivity of Enzymatic Transformations Human Chorionic Gonadotrophin and Ovarian and Placental Steroidogenesis Recent Advances in Our Understanding of the Vitamin D Endocrine SystemSymposia 1. Advances in Steroid Chemistry Total Synthesis of Natural and Non-Natural Steroid Hormones Synthesis and Structure-Activity Relationships in A Novel Series of Topically Active Corticosteroids Seco-Oestradiols and Some Non-Steroidal Oestrogens: Structural Correlates of Oestrogenic Action Water-Soluble Steroidal Anaesthetics 2. Steroid Antagonists Steroid Antagonists: Pharmacological Effects, and Physiological Roles? Action of A Non-Steroid Anti-Androgen, RU 23908, in Peripheral and Central Tissues A Critical Appraisal of the Effects of the Antiandrogen, Cyproterone Acetate, On The Epididymis in Connection With Fertility Control Inthe Male Aromatase Inhibitors and Their Use in Controlling Oestrogendependent Processes 3. Analytical Methods Quality Control of Radioimmunoassay of Hormones in Reproductive Physiology Determination of Steroid Hormones by The Use of Isotope Dilutionmass Spectrometry: A Definitive Method in Clinical Chemistry Automation of Steroid Radioimmunoassays For Clinical and Research Purposes General and Selective Isolation Procedures For GC/MS Analysis of Steroids in Tissues and Body Fluids 4. New Methods of Steroid Analysis On The Assessment of Validity of Steroid Radioimmunoassays Urinary and Plasma Testosterone Glucosiduronate Measurement by A Simple RIA Method Enzyme-Immunoassay of Steroids: Possibilities and Pitfalls Selected Ion Monitoring; A New Approach for the Specific Determination of Steroids in the Lower Picogram Range Non-Radioisotopic Homogeneous Steroid Immunoassays 5. Steroid Synthesis in Isolated Cells Properties of Dispersed Cells From Rat Adrenals Steroid Profiles Formed by Rat Adrenocortical Whole Tissue and Cell Suspensions Under Different Conditions of Stimulation Steriodogenesis in Testicular Cells Steroid Biosynthetic Lesions in Gonadotropin-Desensitized Leydig Cells 6. Steroid-Enzyme Repression/Induction Induction of Steroid Glucuronyltransferase and Repression of Hydroxysteroid Oxidoreductase: Recent Findings Androgen-Dependent Synthesis of A Prostatic Binding Protein by Rat Prostate Effect of Testosterone, Its 5a-Reduced Metabolites and The Corresponding Propionates On Testosterone Metabolism. I-in the Hypothalamus and in the Anterior Pituitary Effect of Testosterone, Its'5a-Reduced Metabolites and The Corresponding Propionates On Testosterone Metabolism. II-in the Ventral Prostate and in Seminal Vesicles Occurrence of Steroidal Allyl Alcohols in Normal Mammary Tissues N Vitro, in Relation To Experimental Mammary Tumours Multiple Response Patterns To Oestrogenic Stimulation in the Avian Liver 7. Steroid-Protein Interactions Oestrogen Binding Function of Alpharfetoprotein The Serum Sex Steroid-Binding Protein. Purification, Characterization and Immunological Properties of the Human and Rabbit Proteins Further Characterization and Immunological Studies of Human Sex Steroid Binding Plasma Protein Binding of Androgens and Progestins in the Human Testis 8. Steroid Receptors: Biosynthesis, Biorhythms Relationship Between Cytosol and Nuclear Oestrogen Receptors and Oestrogen Concentrations in the Fetal Compartment of Guinea-Pig Mechanisms Involved in the Regulation of Steroid Receptor Levels Oestradiol Plus Receptor Complexes in the Brain and Anterior Pituitary Gland: Quantitation and Neuroendocrine Significance Effect of Oestradiol Benzoate, Tamoxifen and Monohydroxytramoxifen On Immature Rat Uterine Progesterone Receptor Synthesis and Endometrial Cell Division Steroid Receptors in Exocrine Glands: The Pancreas and Prostate 9. Receptors: Purification and Properties Purification and Properties of Native Oestradiol Receptor Chicken Oviduct Nuclear Oestrogen Receptors: Aspects of Steroid Hormone Action The Effects of Antioestrogens On The Oestrogen Receptor Purification of Glucocorticoid Receptors From Rat Liver Cytosol. Preparation of Antibodies Against The Major Receptor Proteins and Application of Immunological Techniques To Study Activation and Translocation Antibodies To Estrophilin: Comparison Between Rabbit and Goat Antisera 10. Receptor-Genome Interaction Incorporation of Steroid Hormones in Nuclei of Different Ploidy and Different Phases of the Cell Cycle Regulation of Transcription of the Prostate Genome by Androgens Control by Oestrogen of Reversible Gene Expression: The Vitellogenin Model Support For Chromatin Acidic Proteins As Acceptors For Progesterone in the Chick Oviduct Regulation of Transcription in Rat Thymus Cells by Glucocorticoids The Structure and Regulatory Function(S) of Cortisol Receptor-1: Extragenomic Effects Dependent On The Cortisol Receptor Activation 11. Receptors: Non-Genome Aspects Prostate a-Protein: Subunit Structure, Polyamine Binding, and Inhibition of Nuclear Chromatin Binding of Androgen-Receptor Complex Uterine Progesterone After Progesterone Treatment: On The Disappearance of Cytosolic Progesterone Receptors Stabilization of the Avian Progesterone Receptor by Inhibitors The Role of Eosinophil Receptors in the Non-Genomic Response To Oestrogens in the Uterus 12. Effects of Steroid Therapy Oral Contraceptives and Plasma Protein Metabolism Metabolic Effects of Corticosteroid Therapy in Post-Menopausal Women The Steroid-Cancer Hypothesis and Recent Pertinent Epidemiological Studies 13. Sustained Release Preparations for the Delivery of Fertility Regulating Agents Improved Long-Acting Fertility Regulating Agents: What Are The Problems? Biodegradable Systems for the Sustained Release of Fertility-Regulating Agents Pharmacokinetics and Pharmacodynamics of Sustained Release Systems Intravaginal and Intracervical Devices for the Delivery of Fertility Regulating Agents Values of Steroidal Intrauterine Contraception For Developing Countries 14. Oral Contraceptives and Nutrition The Effects of Depo-Provera On Carbohydrate, Lipids and Vitamin Metabolism The Effects of Oral Contraceptives On Carbohydrate, Lipid, and Protein Metabolism in Subjects With Altered Nutritional Status and in Association With Lactation Oral Contraceptive Use and Vitamin Nutrition Status of Malnourished Women-Effects of Continuous and Intermittent Vitamin Supplements 15. Steroids in Parturition and Pregnancy Control of Placental Endocrine Function; Role of Enzyme Activation in the Onset of Labour Maternal Plasma Total Oestriol and Dehydroepiandrosterone Sulfate Loading Test As Indicators of Feto-Placental Function Or Placental Sulfatase Deficiency Cortisol and Cortisone in Human Fetal Development Steroids in Pregnancy and Parturition in the Marsupial, Macropus Eugenii Metabolism of Fetal and Neonatal Adrenal Steroids 16. Perinatal Steroid Endocrinology Sex Differences in Serum LH and FSH Patterns in Hamsters Exposed To Short Photoperiod Influence of Intrahypothalamic Implants of Antioestrogen Or Aromatase Inhibitor On Development of Sterility Following Neonatal Androgenization in Female Rats Plasma Androgens (Testosterone and 4-Androstenedione) and 17-Hydroxyprogesterone in the Neonatal, Prepubertal and Peripubertal Periods in the Human and The Rat: Differences Between Species Perinatal Regulation of Cortisol in the Primate Hormonal Steroids, Neurbtransmitters and Sexual Differentiation of the Brain 17. Puberty Sequential Hormonal Changes and Activation of the Hypothalamicpituitary-Gonadal Axis Changes Throughout Puberty in Adrenal Secretion After ACTH Interactions of Gonadal Steroids, Gonadotropins and Gonadotropin-Releasing Hormones in Sexual Maturation Role of Sex Steroids in the Initiation of Puberty Changes in Pathways of Steroid Production Taking Place in the Rat Ovary Around The Time of the First Ovulation 18. Steroids and Human Prostatic Tumours C1902-Steroid Transformations in the Human Normal, Hyperplastic and Cancerous Prostate Testosterone 5a-Reductase and The Accumulation of Dihydrotestosterone in Benign Prostatic Hyperplasia A Comparative Study of Binding, Metabolism and Endogenous Levels of Androgens in Normal, Hyperplastic and Carcinomatous Human Prostate Metabolism and Action of Steroid Hormones On Human Benign Prostatic Hyperplasia and Prostatic Carcinoma Grown in Organ Culture Steroid Levels in Cancer of the Prostate-Markers of Tumour Differentiation and Adequacy of Anti-Androgen Therapy 19. Metabolic Defects Male Pseudohermaphroditism Secondary To 5a-Reductase Deficiency-A Model for the Role of Androgens in Both The Development of the Male Phenotype and The Evolution of A Male Gender Identity Steroid Sulphatase Deficiency Mechanisms Establishing The Mineralocorticoid Hormone Patterns in the 17a-Hydroxylase Deficiency Syndrome 20. Steroids in Male Reproduction The Role of Testosterone and Other Hormones in Regulation of LH Suppression of Human Spermatogenesis by Depot Androgen: Potential For Male Contraception Quantitative Determination of Specific Proteins in Rat Epididymis Studies With Cyproterone Acetate For Male Contraception Epididymal and Testicular Enzymes As Monitors For Assessment of Male Antifertility Drugs Immunological Induction of Aspermatogenesis 21. Ovum Maturation Control Mechanisms in Oocyte Growth and Maturation Some Aspects of Oocyte Maturation in Catfish Roles of Cyclic AMP and Calcium in Maturation of Xenopus Laevis Oocytes Control of Chromosome Behavior During Progesterone Induced Maturation of Amphibian Oocytes 22. Ovum Implantation Origin of Oestrogen in Preimplantation Rabbit Blastocysts Hormonal Control of Implantation: A Possible Role of Lysosmal Function in the Embryo-Uterus Interaction The Uterus During Progestation: Hormonal Modulation of Pyridine Nucleotide Activity in Relation To Decidual Sensitivity Experimental Models in the Search For Antigestagenic Compounds With Menses-Inducing Activity Blastocyst Oestrogen: An Essential Factor for the Control of Implantation 23. Steroidogenesis in Granulosa Cells and Corpus Luteum The Production of Progesterone, Androgens and Oestrogens by Human Granulosa Cells in Vitro and in Vivo Intraovarian Control of Progesterone Biosynthesis by Granulosa Cells and Corpus Luteum Control of Steroidogenesis in the Preovulatory Rat Follicle Granulosa-Thecal Cell Interaction in Ovarian Steroidogenesis 24. Steroid Action in CNS and Anterior Pituitary-1 Steroid Hormone Target Cells in the Extrahypothalamic Brain Stem and Cervical Spinal Cord: Neuroendocrine Significance Association of Tritiated Ovarian Steroids With The Rhesus Monkey Brain Androgen Metabolism, Androgen and Oestrogen Receptors in the Male Rat Anterior Pituitary Effects of S-Triazine Herbicides On Hormone-Receptor Complex Formation, 5a-Reductase and 3a-Hydroxysteroid Dehydrogenase Activity At The Anterior Pituitary Level 25. Steroid Action in CNS and Anterior Pituitary-II Functional and Organizational Aspects of Gonadal Steroids in the Pig Brain Nuclear Progesterone Receptors and Characterization of Cytosol Receptors in the Rat Hypothalamus and Anterior Hypophysis Interaction of Oestrogen and of Physiological Progesterone Metabolites in the Control of Gonadotropin Secretion in Vivo Uptake and Metabolism of [3H]-Progesterone and [3H]-5a-Dihydroprogesterone by Rat CNS and Anterior Pituitary: Tissue Concentration of Progesterone Itself Or Metabolites? Oestrogen-Progestin Regulation of Female Sexual Behavior in Guinea-Pigs 26. Steroids and Aging Effects of Oestradiol On Covalent Modifications of Chromosomal Proteins and Transcription of Chromatin of the Brain of Rats of Various Ages Changes in the Mechanisms of Steroid Action During Aging Human Testicular Secretion With Increasing Age Factors Affecting Sex Hormone Levels in Postmenopausal Women The Conversion of Androstenedione To Oestrone and Production of Oestrone in Women With Endometrial Cancer 27. Anabolic Steroids Detection of Anabolic Steroid Administration To Athletes Aspects On The Formation and Detection of Tissue Levels of Anabolic Steroids in Domestic Animals Anabolic Steroid Metabolism in Skeletal Muscle The Efficacy and Mechanism of Action of Anabolic Agents As Growth Promoters in Farm Animals Role of Anabolic Steroids in the Hormonal Regulation of Skeletal Muscle Adaptation Practical Aspects of Screening of Anabolic Steroids in Doping Control With Particular Accent To Nortestosterone Radioimmunoassay Using Mixed Antisera 28. Photoperiodic Control of Steroid Production and Action Photoperiodic Control of Testosterone Metabolism in the Central and Peripheral Structures of Avian Species Photoperiodic Control of Androgen Metabolism and Binding in Androgen Target Organs of Hamsters (Phodopus Sungorus) Pineal Gland and Sympathetic Cervical Ganglia As Sites For Steroid Regulation of Photosensitive Neuroendocrine Pathways 29. Biological Effects of Steroid Antibodies Antibodies To Androgens, and Ovulation in the Ewe Prevention of Implantation by Antiprogesterone Corticosteroid and Corticosteroid Metabolite Levels in Animals Immunized Against Corticosteroids 30. Central Control of Steroid Production Regulation of Gonadal Steroid Rhythms in Rats Hormonal Modification Induced by Chronic Stress in Rats Evidence for the Existence of Extra-Hypophyseal Neural Mechanisms Controlling Ovarian Steroid Secretion Role of the Amygdala and The Organum Vasculosum Laminae Terminalis in the Control of Ovarian Function in the Female Rat Central Sites Controlling Pituitary Secretion in the Rhesus Monkey 31. Steroids and Hypertension Adrenocortical Steroid Hormones in Production of Hypertension in Sheep Genetic Aspects of Plasma Aldosterone Binding Globulins in Families of Patients With Essential Hypertension, Including Isolation of Novel Thermostable Homologues From Plasma and Urine The Interaction of Sodium and Potassium Status, of ACTH and of Angiotensin 2 in the Control of Corticosteroid Secretion Adrenal Sensitivity To Angiotensin II and Undiscovered Aldoster-One Stimulating Factors in Hypertension 32. Diagnostic Relevance of Steroid Assays Progress Towards The Wider Use of Better Steroid Immunoassays Diagnostic Relevance of Oestrogen Estimations in Human Pregnancy