This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the researc

The Mitochondrial Production of Oxygen Radicals and Cellular Aging, Alberto Boveris, Lidia E. Costa, and Enrique CadenasWalking a Tightrope: The Balance Between Mitochondrial Generation and Scavenging of Superoxide Anion, David M. Guidot and Joe M. McCordThe Biochemistry of Nitric Oxide and Peroxynitrite: Implications for Mitochondrial Function, Rakesh P. Patel, Trudy Cornwell, and Victor M. Darley-UsmarOxygen-Dependent Regulation of Biological Functions by Nitric Oxide, Kozo Utsumi, Yoshiki Takehara, Yoko Inai, Munehisa Yabuki, Tomoko Kanno, Manabu Nishikawa, Eisuke F. Sato, and Masayasu InoueProduction of Reactive Oxygen Species in Mitochondria and Age-Associated Pathophysiology: A Reality Check, Henry Jay Forman and Angelo AzziFunctional Roles of Ubiquinone, Jeffery R. Schultz and Catherine Freitag ClarkeMitochondrial Generation of Reactive Oxygen Species and Oxidative Damage During Aging: Roles of Coenzyme Q and Tocopherol, Rajindar S. Sohal, Achim Lass, Liang-Jun Yan, and Linda K. KwongMitochondria and Aging: The Mouse's Tale, Steve EsworthyMitochondria and Apoptosis, Bernard M. Babior, Roberta A. Gottlieb, and Christoph RichterRole of Mitochondria in Oxidative Stress Associated with Aging and Apoptosis: Studies in Intact Cells, Juan Sastre, Federico V. Pallardo, Jose Garcia de la Asuncion, Miguel A. Asensi, Juan M. Esteve, and Jose Vina-RibesThe Role of Iron and Mitochondria in Aging, Patrick B. Walter, Kenneth B. Beckman, and Bruce N. AmesThe Mitochondrial-Lysosomal Axis Theory of Cellular Aging, Ulf T. Brunk and Alexei TermanQuantitative Analysis of Mutations of Mitochondrial DNA During Human Aging, Jorg Napiwotzki, Annette Reith, Andreas Becker, Sandra Leist, and Bernhard KadenbachOxidative Damage and Fragility of Mitochondrial DNA, Takayuki OzawaMitochondria in Cellular Aging and Degeneration, Gino A. Cortopassi and Alice WongMitochondrial Alteration in Aging and Inflammation: A Possible Site of A