An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

Includes supplementary material: sn.pub/extras

I: Basic Science of Tumor Antigens and Immune Activation.- 1 Biology of the Cancer Vaccine Immune Response.- 2 The Rational Design of T-Cell Epitopes With Enhanced Immunogenicity.- 3 Identification of Tumor Antigens Using Subtraction and Microarrays.- 4 Tumor Antigen Discovery With T Cells.- 5 Targeting Viral Antigens for the Treatment of Malignancies.- 6 Immune Defects in Cancer.- 7 Escape of Tumors From the Immune System: Role of the Transforming Growth Factor-ß-Signaling Pathway.- II: General Vaccine and Immunotherapy Strategies.- 8 Immune Adjuvants.- 9 Heterologous Prime-Boost Vaccination in Tumor Immunotherapy.- 10 Peptide-Based Vaccines.- 11 Antibody-Inducing Cancer Vaccines Against Cell-Surface Carbohydrate Antigens.- 12 Anti-Idiotype Vaccines.- 13 Pox Viral Vaccines.- 14 Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches.- 15 Alphaviral-Based Strategies for the Immunotherapy of Cancer.- 16 DNA Vaccines.- 17 Whole-Cell Vaccines.- 18 Gene-Modified Tumor-Cell Vaccines.- 19 Hapten-Modified Tumor Vaccines.- 20 Chaperone Proteins/Heat Shock Proteins As Anticancer Vaccines.- 21 Dendritic Cell Vaccines.- 22 Exosomes for Immunotherapy of Cancer.- 23 Immunocytokines for Cancer Immunotherapy.- 24 T-Cell Adoptive Immunotherapy.- III: Tumor-Specific Vaccine Development.- 25 Melanoma Vaccines.- 26 Allogenic Melanoma Lysate Vaccines.- 27 Renal Cancer Vaccines.- 28 Vaccines for Hematological Malignancies.- 29 Vaccines for the Immunotherapy of Prostate Cancer.- 30 Vaccine Therapy for Breast and Ovarian Cancers.- 31 Vaccine Therapy for Gastrointestinal Cancers.- 32 Vaccines for Lung Cancer.- 33 Vaccines for Other Tumors.- IV: Clinical Trials and Immune Analyses.- 34 Clinical Trial Designs for Therapeutic Vaccine Studies.- 35 Analysis of Cellular ImmuneResponses in Cancer Vaccine Trials.- 36 Analysis of Humoral Immune Responses in Vaccine Trials.- 37 Regulatory Issues Affecting Tumor Vaccines.