Beschreibung:
Leading researchers review the activation of the mammalian immune system by bacterial DNA and its immunostimulatory sequences (ISS), and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS , the process of cell activation, and the potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Includes supplementary material: sn.pub/extras
Part I. IntroductionImmunostimulatory DNA: An OverviewEyal RazHistorical PerspectivesSaburo Yamamoto, Toshiko Yamamoto, and Tohru TokunagaPart II. Receptors and SignalingSignal Transduction Pathways Activated by CpG-DNAHans HäckerA Novel Toll-Like Receptor that Recognizes Bacterial DNAHiroaki Hemmi and Shizuo AkiraActivation of Innate Immunity by Microbial Nucleic AcidsWen-Ming Chu, Xing Gong, and Tony YoonPhosphorothioate Backbone Modification Changes the Pattern of Responses to CpGKatryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, and David A. HumePart III. Cell ActivationActivation of NK Cell by Immunostimulatory Oligo-DNA in Mouse and HumanSaburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, Sumiko Iho, and Tohru TokunagaRegulation of Antigen Presenting Cell Function by CpG-DNADavid Askew, Rose S. Chu, and Clifford V. HardingActivation of B Cells by CpG Motifs in Bacterial DNA, Ae-Kyung Yi and Arthur M. KriegIFN-Dependent Pathways for Stimulation of Memory CD8+ CellsJonathan SprentCross Priming of CD8+ T Cells by Immunostimulatory Sequence DNAHearn Jay Cho, Sandip Datta, and Eyal RazPart IV. Vaccination StrategiesThe Th1 Adjuvant Effect of Immunostimulatory DNA SequencesMaripat Corr and Chih Min TangImmunostimulatory DNA Pre-Priming for the Induction of Th1 and Prevention of Th2 Biased Immune ResponsesHiroko Kobayashi, Elena Martin-Orozco, Kenji Takabayashi, and Anthony A. HornerProtein-Immunostimulatory DNA-Conjugate: A Novel ImmunogenKenji Takabayashi, Helen Tighe, Lucinda Beck, and Hans L. SpiegelbergImmunostimulatory DNA Sequence-Based Mucosal VaccinesAnthony A. HornerEnhancement of the Immunoadjuvant Activity ofImmunostimulatory DNA Sequence by Liposomal DeliveryEli Kedar, Igal Louria-Hayon, Aviva Joseph, Zichria Zakay-Rones, Tomoko Hayashi, Kenji Takabayashi, and Yechezkel Barenholz.Immunostimulatory Sequences in Plasmid VectorsChristina C. N. Wu, Chih Min Tang, Brian Crain, and Maripat CorrPart V. Applications-Infectious DiseaseComparison of CpG DNA with Other Adjuvants for Vaccination Against Hepatitis BMichael J. McCluskie, Risini D. Weeratna, and Heather L. DavisImmunostimulatory DNA-Based Immunization: Hope for an HIV Vaccine?Sandip K. Datta, Anthony A. Horner, Kenji Takabayashi, and Eyal RazImmunoprotective Activity of CpG OligonucleotidesDennis M. Klinman, Ken J. Ishii, and Ihsan GurselProtective Immunity of Immunostimulatory Sequences Against Mycobacterial InfectionTomoko Hayashi, Christine H. Tran, Lucinda Beck, Savita Rao, and Antonino CantanzaroPart VI. Applications-AllergyDNA-Based Immunotherapeutics for Allergic DiseaseAnthony A. Horner and Eyal RazImmunostimulatory DNA for Allergic AsthmaReid K. Ikeda, Kenji Takabayashi, and David BroideCpG Oligodeoxynucleotides in AsthmaKunihiko Kitagaki and Joel N. KlineModulation of Allergic Conjunctivitis by Immunostimulatory DNA Sequence OligonucleotidesAndrea Keane-Myers and Chi-Chao ChanPart VII. Applications-CancerCpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of LymphomaThomas L. Warren and George J. WeinerPart VIII. Inflammation and AutoimmunityThe Antigenicity of Bacterial DNADavid S. PisetskyInflammatogenic Properties of Immunostimulatory DNA SequencesAndrej Tarkowski, L. Vincent Collins, Guo-Min Deng, and Leno MölneThe Role of Immunostimulatory DNA Sequences in ArthritisSarah T.A. Roord, Arash Ronaghy, Berent J.