Despite a decline in developed countries, cancer has consistently maintained its status as one of the top killers since time immemorial. Exploring cancer management and treatment at the molecular level, Biology of Oral Cancer: Key Apoptotic Regulators presents a key molecular event-apoptosis-in relation to genesis and progression of oral cancer. The book uses oral cancers as the specific means to demonstrate the use of apoptotic regulators for controlling cancers. The book comprehensively deals with the different aspects of oral cancer. The authors discuss strategies to leverage apoptotic regulatory mechanisms for better management along with state-of-the-art medical options available for management and treatment. Using an informal writing style that makes the information accessible to a wider audience, each chapter begins with a prologue followed by detailed discussion and concludes with a glimpse into future approaches and challenges. The book examines detection techniques that leverage molecular events associated with oral carcinogenesis to effectively detect oral cancer.A thorough examination of the internal (genetics) and external (carcinogens, radiation, and smoking) factors that cause cancer, the book provides an enhanced understanding of why oral cancer has consistently ranked among the top ten causes of cancer-related mortalities worldwide. It furthers the effective identification of the causal factors and their modulation that can restore cells' normal state and be used to develop increasingly effective modalities.

Cancer a Worldwide Menace Introduction History Selected symptomatic types of cancer Major Causes Behind Cancer Epidemiology Diagnosis and Pathology Conclusion References Oral cancer Introduction Epidemiology Signs and Symptoms Sex and Age distribution Etiology Pathology Staging Molecular basis of oral carcinogenesis Metastasis and survival Individual cancers of oral cavity Conclusion References Proliferative and apoptotic regulation in oral cancer Introduction Regulation cell homeostasis Oncogenes and tumor suppressors Proliferative and anti-proliferative signals Apoptotic and anti-apoptotic signals Conclusion References Apoptotic Regulations Introduction Etymology Mechanisms of apoptosis in cancer Role of apoptotic regulators in rheumatoid arthritis (RA) Role of apoptotic regulators in prostrate carcinoma Conclusion References Dynamics of p53 in oral cancer Introduction Functions and role in causing disease p53 as an oncogene p53 as tumor suppressor Mutations in p53 Apoptotic regulation by p53 Interplay between survivin and p53 Clinicopathological significance of p53 Therapeutic strategies targeting p53 Conclusion References Diagnostic and Therapeutic potential of Apoptotic Marker Introduction Apoptotic markers in Oral Cancer Therapeutics Apoptotic markers in Oral Cancer Diagnostics Conclusion References Expression and regulation of survivin Introduction Molecular organization and structure of survivin Isoforms and functions of survivin Role of survivin in cell regulation and lamphomagenesis Role of survivin in cell division Role of survivin in apoptosis Regulation of survivin Expression of survivin in normal tissues Expression of survivin in human cancer Conclusion References Therapeutics of survivin Introduction Manipulation of survivin gene Factors inducing survivin expression Down regulation of survivin Ribozyme mediated degradation of survivin Immunotherapy Therapeutic biology of survivin Survivin directed cancer therapy Regulation of survivin in head and neck squamous carcinoma Prognostic and diagnostic significance of survivin Therapeutic approach Survivin for cancer immunotherapy Conclusion Reference Molecular diagnosis of oral cancer Introduction Molecular markers for oral cancer Molecular mechanism of development of oral cancer The hall markers of oral cancer Other markers Diagnosis of oral squamous cell carcinoma Conclusion References Glossary Index