Juvenile hormones (JHs) affect most stages of the insect life-cycle as well as their physiological functions. Juvenoids, manmade chemicals that mimic the actions of JHs, can be used to disrupt the endocrine system of insects, making them particularly suited as larvicides for the control of pest and disease vectoring insects. This book presents various modeling approaches and computational methods that can be used to study the mechanism of action of JHs in insects and to estimate the adverse effects and the environmental fate of juvenoids.

Juvenile Hormones and Juvenoids: A Historical Survey. Future Perspectives for Research on the Biosynthesis of Juvenile Hormones and Related Sesquiterpenoids in Arthropod Endocrinology and Ecotoxicology. Morph-Specific JH Titer Regulation in Wing-Polymorphic Gryllus Crickets: Proximate Mechanisms Underlying Adaptive Genetic Modification of JH Regulation. Soldier-Specific Organ Developments Induced by a Juvenile Hormone Analog in a Nasute Termite. Roles of Juvenile Hormone Analog Methoprene in Gene Transcription. Modeling Resistance to Juvenile Hormone Analogs: Linking Evolution, Ecology, and Management. Population Dynamics Models for Assessing the Endocrine Disruption Potential of Juvenile Hormone Analogues on Nontarget Species. SAR and QSAR Modeling of Juvenile Hormone Mimics. Using CoMFA and CoMSIA as Tools in a 3D QSAR Analysis of Juvenile Hormone Agonist Action in Drosophila. Predicting Highly Potent Juvenile Hormone Esterase Inhibitors from 2D QSAR Modeling. Receptor-Guided Structure-Activity Modeling of Inhibitors of Juvenile Hormone Epoxide Hydrolases. Structural Studies of Juvenile Hormone-Binding Proteins. In Silico Stereoelectronic Profile and Pharmacophore Similarity Analysis of Juvenile Hormone, Juvenile Hormone Mimics (IGRs), and Insect Repellents May Aid Discovery and Design of Novel Arthropod Repellents. Use of Multicriteria Analysis for Selecting Candidate Insecticides for Vector Control. Index.