This book represents the fourth ina series of international conferences related to Alzheimer's (AD) and Parkinson's (PO) diseases. The first one took place in EHat, Israel in 1985; the second in Kyoto, Japan, in 1989; and the third in Chicago, IL, USA in 1993. This book incorporates the proceedings of the Fourth International Conference on Pro­ gress in Alzheimer's and Parkinson's Diseases, held in EHat, Israel, on May 18-23, 1997. This Conference was the 41st in the series of annual OHOLO Conferences sponsored by the Israel Institute for Biological Research (IIBR). It was also conducted under the aus­ pices of the Alzheimer's Association Ronald and Nancy Reagan Research Institute, USA. The Conference was attended by 550 participants from 28 countries, representing a broad spectrum of research interests; and included a well-balanced representation from aca­ demia, clinical institutions and pharmaceutical industry. The four-and-one-half day meeting served as an excellent medium for surveying the current preclinical and clinical develop­ ments in AD, PO, and other related disorders. The scientific program was divided into 24 oral sessions and daily poster sessions. The conference culminated in a round table discus­ sion. There were 122 talks and 161 posters. This book incorporates a combination of both.

Pathology in Alzheimer's Disease: General.- Apolipoprotein E.- Apoptosis; Oxidative Stress; Amyloids, Inflammation, and Other Defects.- Amyloid Aggregation.- Tau in Alzheimer's Disease.- Alzheimer's Disease/Parkinson's Disease and Related Disorders: Clinical and Etiological Aspects.- Parkinson's Disease: Etiology, Genetics, Treatment.- Cholinergic Strategies in Alzheimer's and Parkinson's Disease.- Alzheimer's Disease: Muscarinic Treatment and Therapy-?-Amyloids.- Cholinesterase Inhibitors for Treatment of Alzheimer's Disease.- Neurotrophic Factor Therapy: Neuroprotection, Neurotransplantation, and Other Treatment Strategies.- Animal Models in Alzheimer's and Parkinson's Diseases.- Diagnostic Tools in Alzheimer's and Parkinson's Diseases.- Developments in Treatment Strategies in Alzheimer's Disease.