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Design, Analysis, and Interpretation of Genome-Wide Association Scans
ISBN-13:
9781461494430
Veröffentl:
2013
Seiten:
334
Autor:
Daniel O. Stram
Serie:
Statistics for Biology and Health
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study.
¿Introduction to Genome-Wide Association Studies.- Topics of Quantitative Genetics.- An Introduction to Association Studies.- Correcting for Hidden Population Structure in Single Marker Association Testing and Estimation.- Haplotype Imputation for Association Analysis.- SNP Imputation for Association Studies.- Design of Large-scale Genetic Association Studies, Sample Size and Power.- Post-GWAS Analyses.
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