¿This volume covers some of the topics that are related to the rapidly growing field of biomedical informatics. In June 11-12, 2010 a workshop entitled 'Optimization and Data Analysis in Biomedical Informatics' was organized at The Fields Institute. Following this event, invited contributions were gathered based on the talks presented at the workshop, and additional invited chapters were solicited from leading experts. In this publication, the authors share their expertise in the form of state-of-the-art research and review chapters, bringing together researchers from different disciplines and emphasizing the value of mathematical methods in the areas of clinical sciences.

¿¿¿¿Preface.- Novel Biclustering Methods for Re-Ordering DataMatrices (P.A. DiMaggio Jr., A. Subramani, C.A. Floudas).- Clustering TimeSeries Data with Distance Matrices (O. Seref, W.A. Chaovalitwongse).- Mathematical Models of SupervisedLearning and Application to Medical Diagnosis (R. De Asmundis, M.R.Guarracino).- Predictive Model for Early Detection of Mild Cognitive Impairmentand Alzheimer's Disease (E.K. Lee, T.-L. Wu, F. Goldstein, A. Levey).Strategies for Bias Reduction in Estimation of Marginal Means with Data Missingat Random (B. Chen, R.J. Cook).- Cardiovascular Informatics: A Perspective onPromises and Challenges of IVUS Data Analysis (I.A. Kakadiaris, E.G.M. Ruiz).An Introduction to the Analysis of Functional Magnetic Resonance Imaging Data(G. Gazzola, C.-A. Chou, M.K. Jeong, W.A. Chaovalitwongse).- SensoryNeuroprostheses: From Signal Processing and Coding to Neural Plasticity in theCentral Nervous System (F. Panetsos, A. Sanchez-Jimenez, C. Herrera-Rincon).EEG Based Biomarker Identification Using Graph-Theoretic Concepts: Case Studyin Alcoholism (V. Sakkalis, K. Marias).- Maximal Connectivity and Constraintsin the Human Brain (R.V. Belavkin).¿