Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advances in the cellular and molecular biology of breast cancer. As in previous volumes, the editors have invited recognized experts in cutting-edge topics to provide a chapter focused on their area of research. The editors have turned to the researchers who study rodent models of the disease and to those who study the cellular and molecular basis of human breast cancer.The first section of the book is devoted to new mouse models of mammary development and tumorigenesis. The second section moves to studies of human breast cancer and focuses on receptors, signalling, and the cell cycle. The final section deals with defective tissue interactions in human breast cancer.We are now in a period of extremely rapid accumulation of data on the molecular and cellular biology of breast cancer. These findings are highlighted in chapters from Mammary Tumor Cell Cycle, Differentiation and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer.

A. Mouse models of mammary development and tumorigenesis.- 1. Programmed cell death and mammary neoplasia.- 2. Tissue reconstitution or transgenic mammary gland technique for modeling breast cancer development.- 3. Preneoplasia in mammary tumorigenesis.- 4. Transgenic models of breast cancer metastasis.- B. Human breast cancer: Receptors, signaling, and the cell cycle.- 5. Protein kinase C and breast cancer.- 6. Protein tyrosine phosphatases: Cellular regulators of human breast cancer?.- 7. Role of the nuclear matrix in breast cancer.- 8. Cyclins and breast cancer.- 9. Nuclear oncogenes in breast cancer.- 10. Antiprogestin-progestin interactions.- 11. Antiestrogen-estrogen receptor interactions.- C. Human breast cancer: Invastion, Metastasis, Angiogenesis, and Immunology.- 12. Differentiation antigens in stromal and epithelial cells of the breast.- 13. Models of progression spanning preneoplasia and metastasis: The human MCF-10A neo T.TGN series and a panel of mouse mammary tumor subpopulations.- 14. Angiogenesis in breast cancer.- 15. Cell motility in breast cancer.- 16. Cathepsins D and B in breast cancer.- 17. Stromelysin-3 and other stromelysins in breast cancer: Importance of epithelial-stromal interactions during tumor progression.- 18. Endothelins in breast cancer.- 19. Breast cancer immunology.