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Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development
ISBN-13:
9781447149200
Veröffentl:
2014
Seiten:
312
Autor:
Andrew J. Krentz
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease.
1. Review of physiology/pathophysiology.- 2. Methods for assessing insulin action in humans.- 3. Assessment of insulin secretion.- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy.- 5. Isotopic tracers for the measurement of metabolic flux.- 6. Measuring food intake in clinical drug development.- 7. Measurement of energy expenditure.- 8. Assessment of body composition.- 9. Assessment of cardiovascular safety of new diabetes drugs.
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