A vital resource on blood and bone marrow cell morphology inlaboratory animal medicine. This fully revised new edition is anessential reference for clinical pathologists in diagnosticlaboratories, and medical or veterinary research. The atlascontains over 400 color images of cells from the peripheral bloodand bone marrow from a variety of animals encountered in laboratoryanimal medicine, in health and disease.Key features:* New chapter on flow cytometry and its application in terms ofroutine analyses as a means of identifying abnormalities in cellmarker expression, which is of particular relevance forpre-clinical safety assessment* Covers the most recent developments in laboratory animalhematology, including parameters measured by the latest generationof analyzers* Coverage of a wide range of laboratory animal species, as wellas those used in clinical veterinary trials* Photomicrographs present normal and abnormal blood cells from avariety of hematological conditions along with descriptivetext

Foreword viiIntroduction ixDedication xiAcknowledgments xiii1 Rodents 1Mouse 1Introduction 1Blood picture 1Typical ranges (Siemens Advia 120) 2Hamster 15Introduction 15Blood picture 15Guinea Pig 17Introduction 17Blood picture 17Rat - Sprague Dawley (SD)/Han Wistar (HW) 18Introduction 18Blood picture 18Typical ranges (Siemens Advia 120) 19References 362 Rabbit 37Introduction 37Blood picture 37References 394 Dog 45Introduction 45Blood picture 45Typical ranges (Siemens Advia 120) 46References 645 Monkey 65Introduction 65Blood picture 65Marmoset 66Cynomolgus 71Introduction 71Blood picture 71Typical ranges (Siemens Advia 120) 72Baboon 84Rhesus Monkey 86References 876 Other species 89Pig 89Introduction 89Blood picture 89Horse 91Introduction 91Blood picture 91Goat and Sheep 94Assorted Other Species 96References 1033 Cat 41Introduction 41Blood picture 41References 447 Blood collection procedures 105Common bleeding sites 105Anticoagulants 105Staining 1058 Artifacts 107Collection artifacts 107Sample transport and storage 109Anticoagulant 110Storage artifacts 111Blood smear preparation 113Stain precipitate 113References 1149 Bone marrow 115Introduction 115Review of marrow sampling techniques 115Recommended methods for marrow sampling 116Preparation and staining of smears 118Evaluation 119Interpretation 119References 12010 Comparative applications in flow cytometry 121Application of flow cytometry in comparative hematology 122References 132Index 135