This is the latest volume in the IOC Encyclopaedia of SportsMedicine series, summarizing the evidence from all relevantsources on the genetic and molecular basis of sports and otherhuman physical performance.The initial chapters address the basic science of genomics andgenetics and the regulation of gene expression. Additionalchapters provide authoritative information on the genetics ofcomplex performance phenotypes, the contributions of small animalresearch, family and twin studies, and ethnic comparisons. Afinal section addresses the issue of the contribution of specificgenes and molecular markers as related to endurance, strength andpower, and responsiveness to specific conditioningprograms.This latest volume in the Encyclopaedia of Sports MedicineSeries from the Medical Commission of the International OlympicCommittee is a must for sports and exercise scientists who requirea thorough guide to the most cutting edge science in this expandingfield.

List of Contributors.Foreword.Preface.Part 1 The Science of Genomics and Genetics.1 The Human Genome and Epigenome (john j. mulvihill, klaas j.wierenga and chad m. kerksick).2 Mitochondrial Medicine in Health and Disease: InterfaceBetween Athletic Performance and Therapeutics (douglas c.wallace).3 Characterizing the Extent of Human Genetic Variation forPerformance-Related Traits (john blangero and jack w. kentjr.).4 Current Proteome Profiling Methods (yetrib hathout, catherinea. formolo, kristy j. brown and javad nazarian).5 Bioinformatics and Public Access Resources (yue wang, huai li,david j. miller and jianhua xuan).6 Search for Genes Influencing Complex Traits (corneliu henegar,henri hooton and karine clément).Part 2 Evidence from Genetic Epidemiology Studies.7 Genetic Epidemiology, Physical Activity, and Inactivity (mollys. bray, janet e. fulton, nishan sudheera kalupahana and j. timothylightfoot).8 Role of Genetics Factors in Sport Performance: Evidence fromFamily Studies (louis pérusse).9 Twin Studies in Sport Performance (gaston p. beunen, maartenw. peeters and robert m. malina).10 Twin and Family Studies of Training Responses (mark a.sarzynski, tuomo rankinen and claude bouchard).11 Ethnic Differences in Sport Performance (yannis p.pitsiladis).12 Selection Experiments in Rodents to Define the Complexity andDiversity of Endurance Capacity (steven l. britton and laurengerard koch).Part 3 Contributions of Specific Genes and Markers.13 Genes and Endurance Performance (bernd wolfarth).14 Genes and Strength and Power Phenotypes (martine a.i.thomis).15 Genes and Response to Training (tuomo rankinen, mark a.sarzynski and claude bouchard).16 Genetic Determinants of Exercise Performance: Evidence fromTransgenic and Null Mouse Models (eunhee chung and leslie a.leinwand).17 The ACE Gene and Performance (james r.a. skipworth,zudin a. puthucheary, jai rawal and hugh e. montgomery).18 The ACTN3 Gene and Human Performance (daniel g.macarthur and kathryn n. north).19 Mitochondrial DNA Sequence Variation and Performance (shinyakuno, hirofumi zempo and haruka murakami).20 Genes, Exercise, and Lipid Metabolism (yohan bossé).21 Genes, Exercise, and Glucose and Insulin Metabolism (leonidasg. karagounis and john a. hawley).22 Genes, Exercise, and Cardiovascular Phenotypes (james m.hagberg).23 Genes, Exercise, and Protein Metabolism (mark a.tarnopolsky).24 The Regulation of Physical Activity by Genetic Mechanisms: IsThere a Drive to Be Active? (nishan sudheera kalupahana, naimamoustaid-moussa, jung han kim, brynn h. voy, david bassett, mollys. bray and j. timothy lightfoot).25 Genes, Exercise, and Psychological Factors (eco j.c. de geusand marleen h.m. de moor).Part 4 Systems Biology of Exercise and Training.26 A Primer on Systems Biology, as Applied to ExercisePhysiology and Metabolism (james a. timmons and jorn w. helge).27 Systems Biology Through Time Series Data--A Strength ofMuscle Remodeling (monica hubal, zuyi wang anderic p. hoffman).28 Proteomics in Exercise Training Research (dustin s.hittel).29 The Influence of Physical Exercise on Adult Stem Cells (fawzikadi).Part 5 Ethical and Societal Implications.30 Genetics and Ethics in Elite Sport (sigmund loland).31 Genes and Talent Selection (stephen m. roth).32 Performance Enhancement by Gene Doping (anna baoutina).33 Bioethical Concerns in a Culture of Human Enhancement (andymiah).Index.