Staphylococci remain the most important cause of hospital-acquiredinfections in the U.S. and MRSA has become the most common cause ofskin and soft tissue infection in many parts of the world.There is now a much greater understanding of the physiology andevolution of the staphylococci and this new edition reflects therapid advancements in knowledge about this pathogen and provides acomprehensive review from both clinical and basic scienceperspectives.The first section addresses the basic biology of thestaphylococci, their molecular genetics, host defenses and hostevasion, virulence determinants, mechanisms of antibioticresistance, and laboratory techniques. The second section dealswith epidemiology, and the third section provides an overview ofthe varied clinical manifestations of human staphylococcalinfections. The fourth section covers prevention and treatment ofthese often life-threatening infections.Written by experts from around the globe, this book is essentialreading for all clinicians and basic scientists studying thestaphylococci.

Section I: The Organisms Biology and Taxonomy.1 The biology of staphylococci (Greg A. Somerville andRichard A. Proctor).2 Genomics of the Staphylococci. (Steven R. Gill).3 The evolution and taxonomy of staphylococci (Barry N.Kreiswirth, Barun Mathema, José R. Mediavilla and LiangChen).4 The molecular basis of pathogenicity (Mark S. Smeltzer,Chia Y. Lee, Nada Harik and Mark E. Hart).5 Adaptation to stress: biofilms and small colony variants(Karl M. Thompson and Kimberly K Jefferson).6 Exotoxins (Patrick M. Schlievert, John K. McCormick,Gregory A. Bohach and Douglas H. Ohlendorf).7 Host Defense Against Staphylococcal Infection.7a The mechanism of host defense (Hattie D. Gresham).7b Evasion of Host Defenses (Timothy J. Foster).Antimicrobial Resistance in Staphylococci.8 Resistance to beta-lactam antibiotics (BrigitteBerger-Bächi, Maria Magdalena Senn, Miram Ender, Kati Seidl,Judith Hübscher, Bettina Schulthess, Roni Heusser, PatriciaStutzmann Meier and Nadine McCallum).9 Resistance to glycopeptides (Keiichi Hiramatsu).10 Resistance to other agents (David C. Hooper and JacobStrahilevitz).Laboratory Studies.11 Issues in the identification and susceptibility testing ofstaphylococci (Betty A. Forbes).Section II: Epidemiology of Staphylococcal Infection.12 Colonization with Staphylococcus aureus and the role ofcolonization in causing infection (Henri A. Verbrugh).13 Epidemiology of community-associated Staphylococcus aureusinfections (Rachel J. Gorwitz and John A. Jernigan).14 Epidemiology of Healthcare-Associated Staphylococcus aureusInfections (Andrew E. Simor and Mark Loeb).15 Epidemiology of Coagulase-Negative Staphylococci andInfections Caused by these Organisms (Kathie L.Rogers, Paul D.Fey and Mark E. Rupp).Section III: Diseases Caused by Staphylococci.16 Staphylococcus Aureus Bacteremia and Endocarditis (ZeinaA. Kanafani, Sara E. Cosgrove and Vance G. Fowler Jr).17 Surgical Site Infections and Surgical Prophylaxis(Deverick J. Anderson and Keith S. Kaye).18 Infections of Intravascular Catheters and Vascular Devices(Hidetaka Yanagi and Robert J. Sherertz).19 Skin and soft tissue infections (Martin E. Stryjewski,Esteban C. Nannini and G. Ralph. Corey).20 Central nervous system infections (Karen L. Roos).21 Diseases of the Eye (Linda A. Ficker).22 Osteomyelitis and Other Bone and Joint Infections (OdetteC. El Helou, Elie F. Berbari, and Douglas R. Osmon).23 Staphylococcal Pneumonia (Ethan Rubinstein and Marin H.Kollef).24 Urinary tract infections (S. Gatermann and Kent B.Crossley).25 Toxic Shock Syndrome (Aaron DeVries).26 Toxin-mediated syndromes (Tristan Ferry and JeromeEtienne).27 Staphylococcal Diarrhea and Enterocolitis (Mark H.Wilcox).28 Infections in Immunocompromised Patients (Lisa E. Davidsonand Helen W. Boucher).29 Clinical Manifestations of Community-Acquired MRSA Infections(Brian S. Schwartz and Henry F. Chambers).Section IV: Prevention and Treatment of StaphylococcalInfections.30 Elimination of S. aureus carriage: Importance and strategies(Loreen A. Herwaldt and John M. Boyce).31 Treatment of Staphylococcal Infections (Kent B. Crossleyand Joseph John).32 Vaccine-based strategies for prevention of Staphylococcusaureus infection (Adam C. Schaffer and Jean C. Lee).Index.