Heat Shock Proteins in Neural Cells

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Heat Shock Proteins: Expression and Functional Roles in Nerve Cells and Glia.- Small Heat Shock Proteins and the Cytoskeleton: Their Role in Inclusion Body Formation in Glial Cells.- The Role of Hsps in Neuronal Differentiation and Development.- Heme Oxygenase as a Therapeutic Funnel in Nutritional Redox Homeostasis and Cellular Stress Response: Role of Acetylcarnitine.- Heat Shock Proteins and the Regulation of Apoptosis.- Assembly of Protein Aggregates in Neurodegeneration: Mechanisms Linking the Ubiquitin/Proteasome Pathway and Chaperones.- The Role of Heat Shock Proteins during Neurodegeneration in Alzheimer's, Parkinson's and Huntington's Disease.- Heat Shock Proteins in Multiple Sclerosis.
eat shock proteins (HSPs), also called stress proteins, are not only induced in response to elevated temperatures, but also as a result of various stress situations, including environmental strains, viral H infection, ischemia, anoxia and oxidative stress. These stress situations trigger cellular defence mechanisms that act as an emergency system capable of combatting the toxic consequences due to the accumulation of misfolded proteins. Heat shock proteins are involved in many physiological processes, including development and differentiation, organisation of the cytoarchi tecture by binding to cytoskeletal elements and regulation of the balance between cell death and survival. Many heat shock proteins work as molecular chaperones. In this role, they contribute to in vivo protein folding and prevent nonproductive interactions with other proteins and cellular c- ponents. In recent years it has been found that the chaperone system and the proteolytic machinery work closely together, and that proteasomal - hibition causes the upregulation of stress proteins. Impairment of the proteasomal machinery and chaperone functions lead to protein damage, which contributes to neurodegenerative disorders and to the aging process.

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Autor: Christiane Richter-Landsberg
ISBN-13 :: 9781441922939
ISBN: 1441922938
Erscheinungsjahr: 17.09.2011
Verlag: Springer New York
Gewicht: 205g
Seiten: 128
Sprache: Englisch
Auflage 2009
Sonstiges: Taschenbuch, 235x155x7 mm
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