Why another book about vaccines? There are already a few extremely well-written medical textbooks that provide comprehensive, state-of-the-art technical reviews regarding vaccine science. Additionally, in the past decade alone, a number of engrossing, provocative books have been published on various related issues ra- ing from vaccines against specific diseases to vaccine safety and policy. Yet there remains a significant gap in the literature ¿ the history of vaccines. Vaccines: A Biography seeks to fill a void in the extant literature by focusing on the history of vaccines and in so doing, recounts the social, cultural, and scientific history of vaccines; it places them within their natural, historical context. The book traces the lineage ¿ the ¿biography¿ ¿ of individual vaccines, originating with deeply rooted medical problems and evolving to an eventual conclusion. Nonetheless, these are not ¿biographies¿ in the traditional sense; they do not trace an individual¿s growth and development. Instead, they follow an idea as it is conceived and dev- oped, through the contributions of many. These are epic stories of discovery, of risk-takers, of individuals advancing medical science, in the words of the famous physical scientist Isaac Newton, ¿by standing on the shoulders of giants. ¿ One grant reviewer described the book¿s concept as ¿triumphalist¿; although meant as an indictment, this is only partially inaccurate.

The concept and practice of vaccination ranks among the greatest public health achievements of the 20th century

Vaccinology in Context: The Historical Burden of Infectious Diseases.- Smallpox.- A Brief History of Microbiology and Immunology.- Anthrax.- Rabies.- Killed Vaccines: Cholera, Typhoid, and Plague.- Toxoid Vaccines.- Tuberculosis and BCG.- The Discovery of Viruses and the Evolution of Vaccinology.- Yellow Fever.- Influenza.- Polio.- Measles, Mumps, and Rubella.- Diseases of Military Importance.- Varicella and Zoster.- Polysaccharide Vaccines.- Hepatitis B.- Japanese Encephalitis.- Hepatitis A.- Rotavirus.- Human Papillomaviruses.- The Future of Vaccine Discovery and Development.