Chemokine Receptors and NeuroAIDS: Beyond the Co-receptor Function and Links to Other Neuropathologies focuses on unresolved or emerging issues concerning the role of chemokine receptors in neuronal injury and HIV neuropathology, including their ability to regulate fundamental neuronal and glial functions and their role in neurovirulence and neurotoxicity. Although the importance of these molecules in the CNS physiology and pathology is now apparent, these issues are still matter of debate, and further research is required to design effective pharmacological agents that specifically target the brain chemokine system without major side effects.To this end, specific topics have been selected and are reviewed by international experts within the basic science/medical community. This book encourages investigation in the most controversial areas and fosters interaction between clinicians and basic scientists. The book also increases awareness about differences in disease progression among different parts of the world as well as selected patient populations, which may also help identifying novel therapeutic strategies.

Contains contributions by leading international researchers

Chemokine receptors as HIV coreceptors: the brain perspective.- HIV neurotropisms: lessons from the developing world.- CCR5 and CXCR4: different roles at different times.- Co-receptors signaling in neurons.- Roles of monocytes and microglia.- Regulation of glutamate release and uptake: CXCR4 and glia.- CX3CR1, glutamatergic neurotransmission and excitotoxicity.- Chemokines cleavage products in HIVE.- Expression and function of chemokine receptors in neural progenitors.- CXCR4 in neuronal migration and differentiation.- Altered expression of cell cycle proteins in HIVE.- E2F1 and downstream targets in HIV neuropathology.- Regulation of the Rb protein by CXCR4 in differentiated neurons.- Opiates and HIV.- Interaction between opioid and chemokine receptors in immune cells: implications to HIV infection.- Regulation of neuronal CXCR4 by µ-opioid receptors.- Opioids, chemokines and glial.- Opioids regulation of the immune response: what is relevant to HIV.- Chemokines and Alzheimer's.- Chemokines and brain cancer.- Index.