Pediatric and Adolescent Osteosarcoma provides a review of the nature of osteosarcoma and the conflict that accompanied the introduction of adjuvant therapy for osteosarcoma culminating in accepted and prevailing methods of current therapy. It outlines concepts in epidemiology and etiology, and provides chapters on pathology and radiologic characteristics of osteosarcoma, surgical therapy tailored specifically for treatment of primary tumors in pediatric/adolescent age groups, treatment of pulmonary and extra pulmonary metastases and complications, as well as the role of radiation therapy. The volume concludes with a review of differences and similarities in the management of osteosarcoma in adults as compared to pediatrics / adolescents and new laboratory and animal investigations currently in progress to develop effective diagnostic and therapeutic approaches to improve the outcome.

General Aspects of Osteosarcoma.- The Epidemiology of Osteosarcoma.- The Etiology of Osteosarcoma.- Imaging Assessment of Osteosarcoma in Childhood and Adolescence: Diagnosis, Staging, and Evaluating Response to Chemotherapy.- Osteosarcoma Multidisciplinary Approach to the Management from the Pathologist's Perspective.- Conditions that Mimic Osteosarcoma.- Treatment.- Surgical Management of Primary Osteosarcoma.- The Role of Radiotherapy in Oseosarcoma.- Osteosarcoma Lung Metastases Detection and Principles of Multimodal Therapy.- Surgical Treatment of Pulmonary Metastases from Osteosarcoma in Pediatric and Adolescent Patients.- Non-Surgical Treatment of Pulmonary and Extra-pulmonary Metastases.- Review of the Past, Impact on the Future.- Adjuvant Chemotherapy in Osteosarcoma.- Osteosarcoma: Review of the Past, Impact on the Future. The American Experience.- Osteosarcoma: The European Osteosarcoma Intergroup (EOI) Perspective.- The Treatment of Nonmetastatic High Grade Osteosarcoma of the Extremity: Review of the Italian Rizzoli Experience. Impact on the Future.- Osteosarcoma: The COSS Experience.- Treatment of Osteosarcoma. The Scandinavian Sarcoma Group Experience.- Childhood Osteosarcoma: Multimodal Therapy in a Single-Institution Turkish Series.- International Collaboration is Feasible in Trials for Rare Conditions: The EURAMOS Experience.- Pediatric and Adult Osteosarcoma: Comparisons and Contrasts in Presentation and Therapy.- Supportive Care and Quality of Life.- The Role of Physical Therapy and Occupational Therapy in the Rehabilitation of Pediatric and Adolescent Patients with Osteosarcoma.- Caring for Children and Adolescents with Osteosarcoma: A Nursing Perspective.- Prosthetics for Pediatric and Adolescent Amputees.- Functional, Psychosocial andProfessional Outcomes in Long-Term Survivors of Lower-Extremity Osteosarcomas: Amputation Versus Limb Salvage.- Research and Investigation: New and Innovative Strategies.- Bridging the Gap Between Experimental Animals and Humans in Osteosarcoma.- Is There a Role for Immunotherapy in Osteosarcoma?.- Molecular Classification of Osteosarcoma.- Current Concepts on the Molecular Biology of Osteosarcoma.- How the NOTCH Pathway Contributes to the Ability of Osteosarcoma Cells to Metastasize.- The Role of Fas/FasL in the Metastatic Potential of Osteosarcoma and Targeting this Pathway for the Treatment of Osteosarcoma Lung Metastases.- Bone Marrow Micrometastases Studied by an Immunomagnetic Isolation Procedure in Extremity Localized Non-metastatic Osteosarcoma Patients.- Strategies to Explore New Approaches in the Investigation and Treatment of Osteosarcoma.- History of Orthopedic Oncology in the United States.