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Antisense Drug Technology
Principles, Strategies, and Applications, Second Edition
Sofort lieferbar | Lieferzeit: Sofort lieferbar I
ISBN-13:
9781439832509
Veröffentl:
2007
Seiten:
848
Autor:
Stanley T. Crooke
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
2 - DRM Adobe
Sprache:
Englisch
Beschreibung:
Extensively revised and updated, this second edition incorporates lessons learned from first generation clinical trials, evaluates the technology as a whole, and offers new directions and avenues of research and development. The book explains mechanisms of action, pharmacokinetics of delivery, and the therapeutic potential of antisense drugs, ologonucleotides, hybridization-based drugs, duplex RNA, and more. Leading researchers discuss improvements to second generation drugs and consider the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation.
Introduction, The Basics of Oligonucleotide-Based Therapeutics, Hybridization-Based Drugs: Basic Properties 2_-O-Methoxyethyl Oligonucleotides, Hybridization-Based Drugs: Basic Properties Duplex RNA Drugs, Other Chemical Classes of Drugs, Therapeutic Applications, Index
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