A Readily Applicable Framework for Novel Drug DesignIt is only 20 years since the reach of genetic knowledge has allowed for the development of protein biotherapeutics, but in that time the pace has been fast. While the literature abounds, the field has lacked a comprehensive accounting of this progress. Emerging Protein Biotherapeutics consolidates current knowledge of key protein targets important in autoimmunity and cancers, exploring basic aspects and diverse clinical application. Presents Strategies to Exploit Therapeutic UsesIn this volume, leading researchers cover many aspects of biology related to protein targets, ranging from the in vivo role in the disease process, to various strategies exploiting development of these targets for therapeutic use. Each chapter includes background, a discussion of clinical implications, an account of preclinical and clinical testing of various candidates, and a listing of key references. This volume makes the study of protein biotherapeutics accessible at all levels of expertise. It offers an efficient and rational way to grasp the theoretical and experimental knowledge currently available while also providing a deeper understanding of disease processes. Most importantly, it presents a framework that can be readily employed by those looking to develop their own strategies in pursuit of new clinical applications.

INTRODUCTION. Overview of Antibody-Based Therapeutics: Present and Future Promise. BIOLOGICS FOR AUTOIMMUNITY AND INFLAMMATION. Biologic Therapies for Multiple Sclerosis. Biologic Therapies in Rheumatoid Arthritis. Biologic Therapies in Systemic Lupus Erythematosus. Biologic Therapies for Inflammatory Bowel Disease. Biologic Therapies for Psoriasis. TNFa Inhibitors: Emerging Biologic Therapies for the Treatment of Asthma. Protein-Based Therapies in Experimental and Clinical Transplantation. Biologic Therapies for Type 1 Diabetes. BIOLOGICS FOR HEMATOLOGICAL MALIGNANCIES. Biologic Therapies for Acute Myeloid Leukemia/Myelodysplastic Syndrome. Biologic Therapies for Non-Hodgkin Lymphoma and Hodgkin Disease. Biologic Therapies for Chronic Lymphocytic Leukemia. Biologic Therapies for Multiple Myeloma and Plasma Cell Disorders. DEVELOPMENT OF BIOTHERAPIES FOR SOLID TUMORS. Antibody-Based Therapies for Carcinomas. Role of Vascular Targeting Agents in the Treatment of Solid Tumors: Current and Future Developments. Recent Advancements in the Use of Antibody-Drug Conjugates for Cancer Therapy. INDEX.