Examining important aspects of breast cancer, this updated text discusses such topics as the mechanism involved in carcinogenesis, recent developments in endocrine treatment, the relationship among hormone replacement therapy, and much more.

Breast Architecture and the Pathogenesis of Cancer. The Enzymatic Systems in the Formation and Transformation of Estrogens in Normal and Cancerous Human Breast. Control and Potential Clinical Applications. Pregnancy and Breast Cancer. The cellular origins of breast cancer subtypes. The Importance of Estrogen Receptors in Breast Cancer. Progesterone Receptor Isoforms and Human Breast Cancer. Compensatory signaling promoted by anti-hormones and anti-growth factor therapies in breast cancer: a starting point for the development of resistance to targeted treatments. Apoptosis, cell death, and breast cancer. Aromatase Inhibitors and Their Application to the Treatment of Breast Cancer. Aromatase Inhibition In Breast Cancer: Update of Clinical Applications. Testosterone and another androgens in breast cancer: Clinical Implications. Combination of breast cancer prevention with tissue-targeted hormone replacement therapy. Practical progress in the chemoprevention of breast cancer with selective estrogen receptor modulators (SERMs). Oncostatic effect of analogs of LHRH on breast cancer. Vitamin D and Breast Cancer. Insulin-like Growth Factor Signaling in Normal Mammary Gland Development and Breast Cancer Progression. Insulin-like Growth Factor-I and Breast Cancer: Epidemiological and Clinical Data. Proliferation of breast cells by steroid hormones and their metabolites. Lignans and Breast Cancer. Breast Cancer Risk, Soyfood Intake and Isoflavone Exposure: A Review of the In Vitro, Animal, Epidemiologic, and Clinical Literature. Body Size and Breast Cancer. Antiangiogenic therapy of breast cancer: Rationale and clinical results. Cytotoxic Therapy and Other Non-Hormonal Approaches for the Treatment of Metastatic Breast Cancer. Adjuvant and Neoadjuvant Systemic Chemotherapy for Operable and Locally Advanced Breast Cancer. BRCA1, BRCA2, and Hereditary Breast Cancer.