Reflecting the numerous changes in the field since the publication of the previous edition, this third edition of Developmental Toxicology focuses on the mechanisms of developmental toxicity and incorporates current technologies for testing in the risk assessment process. It examines the role of computer modeling and bioinformatics, exploring how these areas can contribute to further understanding the overall process of development. The text also provides complete coverage of such topics as the role of apoptosis, cell-to-cell interactions, the importance of signal transduction, the use of stem cells and zebra fish, as well as whole animal toxicity testing systems.

1. Role of Apoptosis in Normal and Abnormal Development. 2. Signal transduction pathways as targets for teratogens. 3. Nutrition in Developmental Toxicology. 4. Epigenetic Mechanisms-Role of DNA Methylation, Histone Modifications and Imprinting. 5. Personalized Nutrition and Medicine in Perinatal Development. 6. Targeted Gene changes affecting Developmental Toxicity. 7. Use of mammalian in vitro systems, including embryonic stem cells, in developmental toxicity testing. 8. Zebrafish: a Non-Mammalian Model of Developmental Toxicology. 9. Physiologically-Based Pharmacokinetic Modeling in the risk assessment of developmental toxicants. 10. Integration of whole animal developmental toxicity data into risk assessment. 11. Genomic Approaches in Developmental Toxicology. 12. Comparative Bioinformatics and Computational Toxicology. 13. Investigating Drug Effects in Human Pregnancy.