Biological Concepts and Techniques in Toxicology

Introduction and Overview. NEW CONCEPTS AND APPROACHES. Toxicogenomics: Gene Expression Analysis and Computational Tools. Proteomics. The Potential of Metabonomics in Toxicology. Quantitative Structure-Toxicity Relationships Using Chemodescriptors and Biodescriptors. Hormesis: A Key Concept in Toxicology. Chemical Risk Assessment. Toxicokinetics: Fundamentals and Applications in Drug Development and Safety Assessment. Validation of In Vitro Methods for Toxicology Studies. Chemical Mixtures Risk Assessment and Technological Advances. EXAMPLES APPLIED TO PROBLEMS. Risk-Based Approach to Foods Derived for Genetically Engineered Animals. Toxicology of Nanomaterials. The Biological Basis of Experimental Toxicity of Jet Propulsion Fuel-8. Drug Safety Toxicology. Statins and Toxicity. Inhalation Toxicology. Modern Gas Chromatography/Mass Spectrometry in Human Forensic Toxicology