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Biomolecular Action of Ionizing Radiation
ISBN-13:
9781420011920
Veröffentl:
2007
Seiten:
560
Autor:
Shirley Lehnert
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
0 - No protection
Sprache:
Englisch
Beschreibung:
Raising the standard for radiation biology textbooks, this graduate-level text offers an up-to-date analysis of molecular responses in the body induced by ionizing radiation. It presents an in-depth perspective on clinical applications for the treatment of cancer and radiation injuries. Based on a popular course at McGill University, the book clarifies the underlying mechanisms of radiation effects on signal transduction pathways using terms that non-experts in molecular biology can understand. With an emphasis on medical physics, it relates principles of radiobiophysics and key advances with potential applications of ionizing radiation for diagnosis and treatment.
Introduction. Basic radiation physics and chemistry. Basic cell biology and molecular genetics. Methods of cell and molecular radiobiology. Ionizing radiation effects to the cytoplasm. Damage to DNA by ionizing radiation. Repair of radiation damage to DNA. Cellular response to DNA damage. Chromatin structure and radiation sensitivity. Radiation-induced chromosome damage. Modulation of radiation response via signal transduction pathways. Radiation-induced apoptosis. Early and late responding genes induced by ionizing radiation. Cell death, cell survival, and adaptation. Bystander effects and genomic instability. Tumor radiobiology. Radiation biology of nonmammalian species: three eukaryotes and a bacterium.References. Glossary. Index.
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