This leading textbook in the field examines the mechanisms underlying toxicity, particularly the events at the molecular level and the factors that determine and affect toxicity. The new edition is updated to reflect the latest research into the biochemical basis of toxicology and the growing concerns over the adverse effects of drugs, environmental pollution, and occupational hazards.Principles of Biochemical Toxicology, Fourth Edition thoroughly explains dose-response relationships, disposition and metabolism, and toxic responses to foreign compounds, and presents detailed examples to make the mechanisms of toxicity more accessible to students encountering the subject for the first time. Comprehensive in scope with a clear and concise approach, the text includes summary sections, questions and model answers, and thoroughly revised artwork that serves as an essential aid to learning and teaching.

1. Dose-response Relationships. 2. Factors Affecting Toxic Responses: Disposition. 3. Factors Affecting Toxic Responses: Metabolism. 4. Factors Affecting Metabolism, Disposition and Toxicity. 5. Toxic Responses to Foreign Compounds. 6. Biochemical Mechanisms of Toxicity: Specific Examples.