The Paraoxonases: Their Role in Disease Development and Xenobiotic Metabolism

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This book features a distillation of the plenary lectures presented at the International Conference on Paraoxonases, held in Hajdúszoboszló, Hungary, in September 2006. Bringing together the world's foremost experts in the field, it offers a comprehensive, up-to-date, state of the art review of current paraoxonase research.
The Bert La Du Memorial Lecture.- Paraoxonases: An Historical Perspective.- PONs and Atherosclerosis.- Glucose Inactivates Paraoxonase 1 (PON1) and Displaces it from High Density Lipoprotein (HDL) to a Free PON1 Form.- Paraoxonase-1 and Cardiovascular Disease.- Oxidative Stress & Antioxidants and PON1 in Health and Disease.- D-4F Increases Paraoxonase 1 Activity in HDL.- Paraoxonase 1 (PON1), A Junction Between the Metabolisms of Homocysteine and Lipids.- The Role of PON2 and PON3 in Atherosclerosis and Related Traits.- Paraoxonase 1 and Postprandial Lipemia.- PON1 Genotypes and Coronary Heart Disease.- PON1 Structure.- Human Paraoxonase I: A Potential Bioscavenger of Organophosphorus Nerve Agents.- Stabilisation of Active Form of Natural Human PON1 Requires HPBP.- PONs in Disease other than Atherosclerosis.- Paraoxonase-1 in Chronic Liver Diseases, Neurological Diseases and HIV Infection.- Age-Related Alterations in PON1.- PON and Toxicology.- Paraoxonase (PON1) and Organophosphate Toxicity.- Implications of Paraoxonase-1 (PON1) Activity and Polymorphisms on Biochemical and Clinical Outcomes in Workers Exposed to Pesticides.- PON-Genetics and Regulation.- Transcriptional Regulation of the Paraoxonase Genes.- Effect of Lipid Lowering Medications on PON1.- The Functional Consequences of Polymorphisms in the Human PON1 Gene.- Dietary Modulation of Paraoxonase-1 Activity and Concentration in Humans.- PONs Biochemistry.- PONs' Natural Substrates - The Key for their Physiological Roles.- Paraoxonases, Quorum Sensing, And Pseudomonas Aeruginosa.
In September 2006 the 2nd International Conference on Paraoxonases took place in Hajdúszoboszló, Hungary, bringing together the world's foremost experts in the field. The current book is a distillation of the plenary lectures which took place at the meeting, resulting in a comprehensive up-to-date, state-of-the-art review of current paraoxonase research. The book details a unique and novel enzyme whose physiological/pathological function(s) are just starting to be revealed.

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Autor: Michael Aviram
ISBN-13 :: 9781402065606
ISBN: 1402065604
Erscheinungsjahr: 14.11.2007
Verlag: Springer Netherlands
Gewicht: 720g
Seiten: 344
Sprache: Englisch
Auflage 2008
Sonstiges: Buch, 244x164x47 mm
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