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Molecular Mechanisms of Cancer
ISBN-13:
9781402060168
Veröffentl:
2007
Seiten:
645
Autor:
Georg F. Weber
eBook Typ:
PDF
eBook Format:
EPUB
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:
This book describes molecular processes whose deregulation is important in the formation of tumors. The material is developed from basic cell signaling pathways to their roles in the clinical manifestation of specific cancers. Topics covered include molecular events intrinsic to tumor cells (leading to growth deregulation, extended lifespan, and the ability to invade surrounding tissue), protective mechanisms that prevent transformation (including DNA repair and epigenetic regulation), tumor-host interactions (with the endocrine system, the immune system, and blood vessel formation), and the underlying molecular defects of individual cancers.
General Mechanisms of Transformation.- Theories of Carcinogenesis.- Physiologic Correlates of Malignancy.- Alterations Intrinsic to the Tumor Cells.- Cell Division and Survival.- Cellular Senescence.- Invasiveness.- Mechanisms of Regulation of Cancer-related Genes.- DNA Repair.- Epigenetic Regulation of Cancer-Associated Gene Products.- Interaction of the Groups of Cancer-Related Gene Products.- Interactions Between Host and Tumor.- Structural Growth Control.- The Organ Preference of Metastasis Formation.- Angiogenesis.- Interactions with the Immune System.- Endocrine Dysregulation.- Dormancy and Minimal Residual Disease.- Molecular Mechanisms of Individual Malignancies.- Epithelial Tumors.- Hematologic Malignancies.- Mesenchymal Tumors.- Neurologic Tumors.- Tumors of Serous Cavities.- Embryonic Tumors.
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